Effect of age on single- and multiple-dose pharmacokinetics of erythromycin
Miglioli P, Pivetta P, Strazzabosco M, Orlando R, Okolicsanyi L, Palatini P. Effect of age on single- and multiple-dose pharmacokinetics of erythromycin. European Journal Of Clinical Pharmacology 1990, 39: 161-164. PMID: 2253666, DOI: 10.1007/bf00280051.Peer-Reviewed Original ResearchConceptsElderly subjectsEffect of ageSerum concentrationsSerum concentration-time curveMultiple-dose pharmacokineticsApparent oral clearanceMultiple-dose regimenPeak serum concentrationHealthy elderly subjectsConcentration-time curvePharmacokinetics of erythromycinNormal elderly subjectsYoung healthy adultsMean eliminationTwo-fold accumulationFirst doseOral clearanceOral dosesMultiple dosesMultiple dosingPresystemic clearanceTime-dependent reductionErythromycin stearateAge-related differencesElderly group