Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic
Cadamuro M, Lasagni A, Lamarca A, Fouassier L, Guido M, Sarcognato S, Gringeri E, Cillo U, Strazzabosco M, Marin JJ, Banales JM, Fabris L. Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic. Expert Opinion On Investigational Drugs 2021, 30: 377-388. PMID: 33622120, PMCID: PMC8194059, DOI: 10.1080/13543784.2021.1880564.Peer-Reviewed Original ResearchConceptsExtrahepatic CCAMinority of patientsComplex molecular landscapePro-oncogenic pathwaysSystematic literature searchDeep phenotyping studyOutcome predictorsExtrahepatic cholangiocarcinomaOverlooked diseaseActionable driversClinical developmentActionable targetsMolecular alterationsOncogenic driversTumor microenvironmentHeterogeneous tumorsLiterature searchDistinct entityMolecular profilingSpecific alterationsMolecular landscapePrecision medicinePerturbed pathwaysImmunotherapyPhenotyping studies