335-OR: Lipid-Induced Insulin Resistance in the Renal Cortex Is Associated with Plasma Membrane Sn-1,2-diacylglycerol Accumulation and PKCe Translocation
HUBBARD B, GASPAR R, ZHANG D, KAHN M, NASIRI A, ZHANG X, CLINE G, SHULMAN G. 335-OR: Lipid-Induced Insulin Resistance in the Renal Cortex Is Associated with Plasma Membrane Sn-1,2-diacylglycerol Accumulation and PKCe Translocation. Diabetes 2021, 70 DOI: 10.2337/db21-335-or.Peer-Reviewed Original ResearchHigh-fat dietInsulin receptorInsulin resistanceLipid-Induced Insulin ResistanceRC miceProtein kinase CεRegular chowHFD miceRenal cortexCitrate synthase fluxHyperinsulinemic-euglycemic clamp conditionsAktS473 phosphorylationFatty acid fluxPyruvate oxidationPKCε translocationPyruvate dehydrogenase fluxPhosphorylationDiacylglycerol accumulationHFD feedingFat dietSpouse/partnerFold increaseSynthase fluxTranslocationIonis Pharmaceuticals