2015
Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body
Sitaraman D, Aso Y, Jin X, Chen N, Felix M, Rubin GM, Nitabach MN. Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body. Current Biology 2015, 25: 2915-2927. PMID: 26455303, PMCID: PMC4654684, DOI: 10.1016/j.cub.2015.09.017.Peer-Reviewed Original ResearchConceptsSynaptic microcircuitsDrosophila mushroom bodyKenyon cellsMushroom bodiesMB neuronsControl of sleepHomeostatic rebound sleepHomeostatic sleep regulationIncreases sleepRebound sleepSleep regulationMBONsSleep deprivationNeuron classesSleepSleep informationMemory centerSpecific functional connectionsFunctional connectionsNeuronsPhysiological approachDifferent populationsMicrocircuits
2014
Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila
Kunst M, Hughes ME, Raccuglia D, Felix M, Li M, Barnett G, Duah J, Nitabach MN. Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila. Current Biology 2014, 24: 2652-2664. PMID: 25455031, PMCID: PMC4255360, DOI: 10.1016/j.cub.2014.09.077.Peer-Reviewed Original ResearchConceptsPigment-dispersing factorNeuropeptide calcitonin gene-related peptideCalcitonin gene-related peptideGene-related peptidePDF receptorClock neuronsCircadian clock neuronsDistinct neuronal pathwaysNeuropeptide pigment-dispersing factorDorsal clock neuronsAmount of sleepHomeostatic sleep driveNeurons actsCalcitonin geneNeuronal pathwaysTiming of sleepSleepMental healthSleep driveReceptorsNovel roleCircadian rhythmDH31NeuronsLocomotor rhythm