2020
Frontiers in Celiac Disease
Patel N, Robert ME. Frontiers in Celiac Disease. The American Journal Of Surgical Pathology 2020, 46: e43-e54. PMID: 33739793, DOI: 10.1097/pas.0000000000001639.Peer-Reviewed Original ResearchConceptsCeliac diseaseType II refractory celiac diseaseMonoclonal T-cell populationChildhood viral infectionsDuodenal mucosal histologyImportant autoimmune diseasesRefractory celiac diseaseCommon autoimmune disorderT cell populationsCeliac disease patientsCeliac disease pathogenesisEvaluation of responseCeliac disease manifestationsGluten toleranceDietary glutenGluten exposureMechanisms of diseaseAutoimmune conditionsHLA-DQ2Mucosal histologySymptomatic diseaseInflammatory cascadeInitial diagnosisPatient's symptomsAutoimmune disordersImmune Checkpoint Inhibitor–Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease
Irshaid L, Robert ME, Zhang X. Immune Checkpoint Inhibitor–Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease. Archives Of Pathology & Laboratory Medicine 2020, 145: 191-200. PMID: 33501492, DOI: 10.5858/arpa.2019-0700-oa.Peer-Reviewed Original ResearchConceptsHelicobacter pylori gastritisUpper gastrointestinal tractCeliac diseasePylori gastritisCPI therapyCD8 ratioDuodenal biopsiesInflammatory changesLymphoid aggregatesGastrointestinal tractAnti-programmed death receptor-1/Anti-cytotoxic T-lymphocyteDeath receptor-1/Immune checkpoint inhibitor therapyImmune-related adverse eventsDeath ligand 1 antibodyColonic mucosal changesGastrointestinal tract inflammationLamina propria CD3Lamina propria inflammationUpper gastrointestinal biopsiesUpper gastrointestinal injuryCheckpoint inhibitor therapyH pylori gastritisCD8 T cells
2018
Statement on Best Practices in the Use of Pathology as a Diagnostic Tool for Celiac Disease
Robert ME, Crowe SE, Burgart L, Yantiss RK, Lebwohl B, Greenson JK, Guandalini S, Murray JA. Statement on Best Practices in the Use of Pathology as a Diagnostic Tool for Celiac Disease. The American Journal Of Surgical Pathology 2018, 42: e44-e58. PMID: 29923907, DOI: 10.1097/pas.0000000000001107.Peer-Reviewed Original ResearchConceptsDuodenal mucosal biopsiesCeliac diseaseMucosal biopsiesPossible celiac diseaseUse of pathologySpecific serological testsUse of endoscopyEndoscopic findingsIntraepithelial lymphocytesPathologic assessmentPathologic findingsVillous architectureNorth American AssociationPathology formsBiopsy interpretationBiopsySerological testsTissue samplingDiseasePatientsDiagnostic toolDiagnosisAmerican AssociationPathologistsCritical appraisal
2017
ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation
Rostami K, Marsh M, Johnson M, Mohaghegh H, Heal C, Holmes G, Ensari A, Aldulaimi D, Bancel B, Bassotti G, Bateman A, Becheanu G, Bozzola A, Carroccio A, Catassi C, Ciacci C, Ciobanu A, Danciu M, Derakhshan M, Elli L, Ferrero S, Fiorentino M, Fiorino M, Ganji A, Ghaffarzadehgan K, Going J, Ishaq S, Mandolesi A, Mathews S, Maxim R, Mulder C, Neefjes-Borst A, Robert M, Russo I, Rostami-Nejad M, Sidoni A, Sotoudeh M, Villanacci V, Volta U, Zali M, Srivastava A. ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation. Gut 2017, 66: 2080. PMID: 28893865, PMCID: PMC5749338, DOI: 10.1136/gutjnl-2017-314297.Peer-Reviewed Original ResearchConceptsIntraepithelial lymphocyte countsReceiver operating characteristicIntraepithelial lymphocytesCoeliac diseaseMarsh III lesionsIII lesionsHistological diagnosis of coeliac diseaseNormal controlsReceiver operating characteristic curve analysisDiagnosis of coeliac diseaseOptimal cut-off pointReceiver operating characteristic analysisOptimal cut-offCount intraepithelial lymphocytesCut-off pointCut-offHistological diagnosisLymphocyte countMulticentre studyDuodenal biopsiesAntigenic influenceCurve analysisBiopsyDose responseControl group
2015
American Gastroenterological Association Institute Technical Review on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions
Allen J, Katzka D, Robert M, Leontiadis G. American Gastroenterological Association Institute Technical Review on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions. Gastroenterology 2015, 149: 1088-1118. PMID: 26278504, DOI: 10.1053/j.gastro.2015.07.040.Peer-Reviewed Original Research
2008
A Comparison of Hepatopathologists' and Community Pathologists' Review of Liver Biopsy Specimens From Patients With Hepatitis C
Robert M, Sofair AN, Thomas A, Bell B, Bialek S, Corless C, Van Ness G, Huie–White S, Stabach N, Zaman A. A Comparison of Hepatopathologists' and Community Pathologists' Review of Liver Biopsy Specimens From Patients With Hepatitis C. Clinical Gastroenterology And Hepatology 2008, 7: 335-338. PMID: 19138761, PMCID: PMC4603363, DOI: 10.1016/j.cgh.2008.11.029.Peer-Reviewed Original ResearchConceptsHepatitis C patientsCommunity pathologistsBiopsy specimensC patientsLiver biopsyFibrosis stageInterobserver agreementChronic liver diseaseLiver biopsy specimensPopulation-based studyStage of fibrosisPopulation-based sampleGood overall interobserver agreementOverall interobserver agreementBiopsy specimen sizeDisease surveillance networksHepatitis CLiver histologyLiver diseaseHepatic fibrosisGeneral pathologistsStudy pathologistsHepatopathologistBiopsy samplesPatients
2004
Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis
Robert M, Tang L, Hao L, Reyes-Mugica M. Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis. The American Journal Of Surgical Pathology 2004, 28: 183-189. PMID: 15043307, DOI: 10.1097/00000478-200402000-00005.Peer-Reviewed Original ResearchConceptsColonic mucosal biopsiesCrypt architectural distortionYears of ageEpithelial injuryMucosal biopsiesUlcerative colitisHistological featuresArchitectural distortionRectal biopsyCrypt abscessesPresentation of ulcerative colitisYears of follow-upInitiation of therapyPlasma cell infiltrationDiagnosis of ulcerative colitisPattern of inflammationDegree of colitisDegree of inflammationAge groupsDiagnosed ulcerative colitisPathological confirmationInitial presentationCrypt branchingNo significant differenceHistological criteria
2000
The Histologic Spectrum and Clinical Outcome of Refractory and Unclassified Sprue
Robert M, Ament M, Weinstein W. The Histologic Spectrum and Clinical Outcome of Refractory and Unclassified Sprue. The American Journal Of Surgical Pathology 2000, 24: 676-687. PMID: 10800986, DOI: 10.1097/00000478-200005000-00006.Peer-Reviewed Original ResearchConceptsSmall bowel biopsyBowel biopsyCollagenous sprueUnclassified sprueRefractory patientsCeliac diseaseNormal duodenal biopsiesResidual mucosal abnormalityResponsive celiac diseaseSetting of malabsorptionGluten-free dietTotal parenteral nutritionGroup of patientsLong-term followB-cell lymphomaSubtle histologic changesMucosal thinningPersistent malabsorptionDuodenal biopsiesParenteral nutritionRefractory courseRefractory diseaseNonspecific findingsClinical outcomesChronic inflammation
1999
Biliary Tract Obstruction Secondary to Mycosis Fungoides: A Case Report
Madsen J, Tallini G, Glusac E, Salem R, Braverman I, Robert M. Biliary Tract Obstruction Secondary to Mycosis Fungoides: A Case Report. Journal Of Clinical Gastroenterology 1999, 28: 56-60. PMID: 9916670, DOI: 10.1097/00004836-199901000-00015.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary treeMycosis fungoidesBiliary treeObstructive jaundiceCutaneous T-cell lymphomaMonoclonal T-cell populationMixed lymphocytic infiltratePrevious skin biopsiesBiliary tract obstructionT cell populationsT-cell lymphomaGene rearrangement studiesObstructive symptomsTract obstructionLiver involvementSurgical resectionIsolated involvementLymphocytic infiltrateEndoscopic examinationExtrahepatic ductsAtypical cellsCase reportSkin biopsiesFungoidesMultiple organs
1993
Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease.
Bernstein C, Robert M, Eysselein V. Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. The American Journal Of Gastroenterology 1993, 88: 908-13. PMID: 7684884.Peer-Reviewed Original ResearchConceptsSubstance P concentrationsSubstance P levelsCrohn's diseaseUlcerative colitisSubstance PIncreasing concentrations of substance PConcentrations of substance PPathogenesis of ulcerative colitisRectal mucosal biopsiesNon-inflammatory bowel disease patientsMucosal neutrophilsUC patientsMucosal levelMucosal biopsiesCD patientsAffected patientsIncreased inflammationInflammatory cellsRectal diseaseColonic mucosaInflammatory processPatientsDisease patientsBiopsyMotor phenomena
1992
Cerebral Hemorrhage With Biopsy-Proved Amyloid Angiopathy
Yong W, Robert M, Secor D, Kleikamp T, Vinters H. Cerebral Hemorrhage With Biopsy-Proved Amyloid Angiopathy. JAMA Neurology 1992, 49: 51-58. PMID: 1728264, DOI: 10.1001/archneur.1992.00530250055016.Peer-Reviewed Original ResearchConceptsBiopsy specimensAcute clinical presentationComputed tomographic scanFocal neurological deficitsBrain biopsy specimensTransient ischemic attackBiopsy-provedClinical presentationRing enhancementLoss of consciousnessRadiological featuresImpending hemorrhageTomographic scanIntracerebral hemorrhageLobar hemorrhageNeurological deficitsBiopsy materialImmunohistochemical findingsImmunohistochemical studiesIntraparenchymal bleedingHemorrhageCerebral hemorrhageIschemic attackBrain hemorrhagePatients