2020
Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors.
Perdigoto AL, Tran T, Patel N, Clark P, Patell K, Stamatouli AM, Reddy V, Clune J, Herold KC, Robert ME, Kluger HM. Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors. Clinical Oncology Case Reports 2020, 3 PMID: 33778814, PMCID: PMC7993656.Peer-Reviewed Original ResearchCheckpoint inhibitor therapyElective colectomyUlcerative colitisInhibitor therapyMetastatic melanomaImmune-related adverse eventsExcellent tumor responseImmune checkpoint inhibitorsSevere ulcerative colitisActive ulcerative colitisCheckpoint inhibitor immunotherapyCheckpoint inhibitor treatmentInflammatory bowel diseaseEffective treatment optionBenefits of treatmentImmune system activationTumor cell destructionCheckpoint inhibitorsAdvanced malignanciesAdverse eventsSelect patientsBowel diseaseAutoimmune diseasesTreatment optionsTumor response
2004
Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis
Robert M, Tang L, Hao L, Reyes-Mugica M. Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis. The American Journal Of Surgical Pathology 2004, 28: 183-189. PMID: 15043307, DOI: 10.1097/00000478-200402000-00005.Peer-Reviewed Original ResearchConceptsColonic mucosal biopsiesCrypt architectural distortionYears of ageEpithelial injuryMucosal biopsiesUlcerative colitisHistological featuresArchitectural distortionRectal biopsyCrypt abscessesPresentation of ulcerative colitisYears of follow-upInitiation of therapyPlasma cell infiltrationDiagnosis of ulcerative colitisPattern of inflammationDegree of colitisDegree of inflammationAge groupsDiagnosed ulcerative colitisPathological confirmationInitial presentationCrypt branchingNo significant differenceHistological criteria
1997
Characterization of afferent mechanisms in ileoanal pouches.
Bernstein C, Rollandelli R, Niazi N, Robert M, Hirsh T, Munakata J, Mayer E. Characterization of afferent mechanisms in ileoanal pouches. The American Journal Of Gastroenterology 1997, 92: 103-8. PMID: 8995947.Peer-Reviewed Original ResearchConceptsIleoanal pouchPouch complianceProximal ileumActive ulcerative colitisAnal sphincter functionAfferent nerve functionBalloon distentionIntrapouch pressureS3 dermatomesNerve functionPouch functionSphincter functionAfferent mechanismsUlcerative colitisAfferent innervationClinical featuresClinical presentationColorectal inflammationReferral patternsReflex functionReflex regulationAfferent pathwaysDistention pressuresLower volume thresholdRamp distention
1996
Diffuse colonic mantle cell lymphoma in a patient with presumed ulcerative colitis: detection of a precursor monoclonal lymphoid population using polymerase chain reaction and immunohistochemistry.
Robert M, Kuo F, Longtine J, Sklar J, Schrock T, Weidner N. Diffuse colonic mantle cell lymphoma in a patient with presumed ulcerative colitis: detection of a precursor monoclonal lymphoid population using polymerase chain reaction and immunohistochemistry. The American Journal Of Surgical Pathology 1996, 20: 1024-31. PMID: 8712289, DOI: 10.1097/00000478-199608000-00011.Peer-Reviewed Original ResearchConceptsUlcerative colitisColonic lymphomaMantle cell lymphomaMucosal changesCell lymphomaInflammatory mucosal changesPrimary colonic lymphomaSevere ulcerative colitisImmunoglobulin heavy chain gene rearrangementHigh-grade morphologyHeavy chain gene rearrangementMonoclonal lymphoid populationLate complicationsMucosal injuryUnderlying diseasePrimary lymphomaFurther workupInitial diagnosisResection specimenPolymerase chain reactionSuperficial biopsiesLymphoid proliferationsColitisLymphoid populationsLymphoma
1993
Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease.
Bernstein C, Robert M, Eysselein V. Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. The American Journal Of Gastroenterology 1993, 88: 908-13. PMID: 7684884.Peer-Reviewed Original ResearchConceptsSubstance P concentrationsSubstance P levelsCrohn's diseaseUlcerative colitisSubstance PIncreasing concentrations of substance PConcentrations of substance PPathogenesis of ulcerative colitisRectal mucosal biopsiesNon-inflammatory bowel disease patientsMucosal neutrophilsUC patientsMucosal levelMucosal biopsiesCD patientsAffected patientsIncreased inflammationInflammatory cellsRectal diseaseColonic mucosaInflammatory processPatientsDisease patientsBiopsyMotor phenomena