Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.
Einarsson O, Geba G, Zhu Z, Landry M, Elias J. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. Journal Of Clinical Investigation 1996, 97: 915-924. PMID: 8613544, PMCID: PMC507136, DOI: 10.1172/jci118514.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIL-11 productionParainfluenza virus type 3Airway hyperresponsivenessIL-11Viral upper respiratory tract infectionUpper respiratory tract infectionBALB/c miceSimplex virus type 2Viral-induced asthmaViral respiratory infectionsRespiratory tract infectionsNonspecific airway hyperresponsivenessVirus type 2Virus type 3Clinical bronchospasmAirway dysfunctionAirway physiologyTract infectionsRespiratory infectionsRespiratory virusesSyncytial virusC miceNasal aspiratesViral infectionRhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.
Zhu Z, Tang W, Ray A, Wu Y, Einarsson O, Landry ML, Gwaltney J, Elias JA. Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation. Journal Of Clinical Investigation 1996, 97: 421-430. PMID: 8567963, PMCID: PMC507033, DOI: 10.1172/jci118431.Peer-Reviewed Original ResearchConceptsIL-6 productionIL-6RV infectionPotent stimulatorIL-6 protein productionIL-6 siteSymptomatic RV infectionsNuclear factor kappa BFactor kappa BIL-6 mRNA accumulationNF-kappa B activationNF-kappa B DNA binding activityPromoter-driven luciferase activityRhinovirus stimulationRV challengeNF-kappa BNF-kappa B siteInterleukin-6Nasal washingsKappa BSymptomatic volunteersRhinovirusStimulation pathwayNuclear factorB activation