2024
Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug Delivery SystemsFemaleHumansMacrophagesMiceMice, Inbred C57BLNanoparticlesPolymersTissue DistributionConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-life
1995
Differential expression of ORCC and CFTR induced by low temperature in CF airway epithelial cells
Egan M, Schwiebert E, Guggino W. Differential expression of ORCC and CFTR induced by low temperature in CF airway epithelial cells. American Journal Of Physiology 1995, 268: c243-c251. PMID: 7530908, DOI: 10.1152/ajpcell.1995.268.1.c243.Peer-Reviewed Original ResearchConceptsCl- channel activityAirway epithelial cellsEpithelial cellsCFTR Cl- channel activityProtein kinase ANonepithelial cell typesMutant proteinsKinase ACF airway epithelial cellsIon channel expressionDifferential expressionIncubation temperatureCell typesCF airway epitheliaChannel expressionRegulator mutationsCFTRMultiple alterationsMutationsCells