2000
Identification of the Cystic Fibrosis Transmembrane Conductance Regulator Domains That Are Important for Interactions with ROMK2*
Cahill P, Nason M, Ambrose C, Yao T, Thomas P, Egan M. Identification of the Cystic Fibrosis Transmembrane Conductance Regulator Domains That Are Important for Interactions with ROMK2*. Journal Of Biological Chemistry 2000, 275: 16697-16701. PMID: 10748197, DOI: 10.1074/jbc.m910205199.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorR domainCAMP-activated chloride channelFunctional chloride channelChloride channelsFibrosis transmembrane conductance regulatorFirst transmembrane domainTransmembrane domain 2Transmembrane domain 1Transmembrane conductance regulatorRegulator domainFold domainCFTR domainsTransmembrane domainCFTR regulationCFTR constructsConductance regulatorFirst nucleotideDomain 2Regulatory propertiesDomain 1Ion channelsXenopus oocytesPhosphorylationGlibenclamide sensitivity
1999
CFTR Is a Conductance Regulator as well as a Chloride Channel
SCHWIEBERT E, BENOS D, EGAN M, STUTTS M, GUGGINO W. CFTR Is a Conductance Regulator as well as a Chloride Channel. Physiological Reviews 1999, 79: s145-s166. PMID: 9922379, DOI: 10.1152/physrev.1999.79.1.s145.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorConductance regulatorABC transportersCassette transporter gene familyCFTR Cl- channel functionTransporter gene familyFamily of transportersChloride channelsFibrosis transmembrane conductance regulatorCl- channel functionABC transporter familyTransmembrane conductance regulatorIon channel proteinsCystic fibrosis epitheliaGene familyCellular functionsCellular proteinsTransporter familyChannel proteinsCF geneAmino acidsIon channelsRegulatorTransportersCl- channels