2024
Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnhedoniaBrainFemaleHumansLipopolysaccharidesMaleMicrogliaMiddle AgedNeuroimmunomodulationPositron-Emission TomographyReceptors, GABAStress Disorders, Post-TraumaticConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedonia
2020
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14Sex FactorsStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderPeripheral immune activationImmune activationHigher C-reactive protein levelsC-reactive protein levelsTSPO availabilityTranslocator proteinBrain microglial activationTomography brain imagingStress-related pathophysiologyPositron emission tomography (PET) brain imagingNeuroimmune activationMicroglial activationPTSD symptom severityImmunologic regulationPostmortem studiesPTSD subgroupHealthy individualsSymptom severityTrauma exposurePTSD groupStress disorderLower relative expressionBrain imagingPET imaging
2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressionDepressive Disorder, MajorFemaleHumansMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsPositron-Emission TomographyStress Disorders, Post-TraumaticSynapsesConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterations
2018
Relation Between Sexual and Gender Minority Status and Suicide Attempts Among Veterans Seeking Treatment for Military Sexual Trauma
Sexton MB, Davis MT, Anderson RE, Bennett DC, Sparapani E, Porter KE. Relation Between Sexual and Gender Minority Status and Suicide Attempts Among Veterans Seeking Treatment for Military Sexual Trauma. Psychological Services 2018, 15: 357-362. PMID: 30080095, DOI: 10.1037/ser0000207.Peer-Reviewed Original ResearchMeSH KeywordsCrime VictimsCulturally Competent CareFemaleHumansMaleMilitary PersonnelRisk FactorsSex FactorsSex OffensesSexual and Gender MinoritiesStress Disorders, Post-TraumaticSuicidal IdeationSuicide, AttemptedVeteransConceptsMilitary sexual traumaSuicide attemptsAdditional risk factorsSimilar clinical profilesSemistructured clinical interviewTrauma-focused interventionsMilitary service membersClinical profileMorbidity outcomesClinical managementRisk factorsPsychiatric sequelaeDiagnostic evaluationClinical InterviewConsultation appointmentSuicidal behaviorDemographic characteristicsMinority veteransService membersVeteransSexual traumaCompetent deliveryResearch disparitiesSGM populationsSequelae
2017
A psychometric evaluation of the Posttraumatic Cognitions Inventory with Veterans seeking treatment following military trauma exposure
Sexton MB, Davis MT, Bennett DC, Morris DH, Rauch SAM. A psychometric evaluation of the Posttraumatic Cognitions Inventory with Veterans seeking treatment following military trauma exposure. Journal Of Affective Disorders 2017, 226: 232-238. PMID: 29017066, DOI: 10.1016/j.jad.2017.09.048.Peer-Reviewed Original ResearchConceptsPosttraumatic Cognitions InventoryMilitary sexual traumaPosttraumatic stress disorderTrauma-related beliefsMilitary trauma exposureTrauma-focused treatmentTrauma exposureFactor modelTrauma typesStress disorderSexual traumaCritical constructsSalient relationshipsMilitary traumaStress exposurePsychometric evaluationFactor scoresSubscale scoresReliability validityConfirmatory analysisStandard assessmentVeteransInventoryValidityTraumaAltered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence
Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Kowall N, Brady C, McKee A, Stein T, Huber B, Kaloupek D, Alvarez V, Benedek D, Ursano R, Williamson D, Cruz D, Young K, Duman R, Krystal J, Mash D, Hardegree M, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMGluR5 availabilityPositron emission tomographyGlutamate systemMetabotropic glutamate receptor 5Treatment of PTSDHuman posttraumatic stress disorderGlutamate receptor 5Mechanism-based treatmentsExpression of FKBP5Promising treatment targetHuman postmortem tissueTargeted pharmacological treatmentStress psychopathologyPharmacological treatmentExpression of proteinsReceptor 5MGluR5Treatment targetsPostmortem tissueEmission tomographyStress disorderPostmortem samplesPromising targetDisordersPosttraumatic Stress Disorder Symptom Clusters and Acquired Capability for Suicide: A Reexamination Using DSM‐5 Criteria
Spitzer EG, Zuromski KL, Davis MT, Witte TK, Weathers F. Posttraumatic Stress Disorder Symptom Clusters and Acquired Capability for Suicide: A Reexamination Using DSM‐5 Criteria. Suicide And Life-Threatening Behavior 2017, 48: 105-115. PMID: 28261858, DOI: 10.1111/sltb.12341.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorder (PTSD) symptom clustersPTSD symptom clustersSymptom clustersSpecific PTSD symptom clustersSix-factor Anhedonia modelTrauma-exposed undergraduatesInterpersonal-psychological theoryDSM-5 criteriaAcquired CapabilitySuppressor variableCommonality analysisAnhedonia modelBivariate correlationsSuicideComplex relationshipAnhedoniaFacetsUndergraduatesRelationshipStructure coefficientsFindingsTheory
2016
“Do you expect me to receive PTSD care in a setting where most of the other patients remind me of the perpetrator?”: Home-based telemedicine to address barriers to care unique to military sexual trauma and veterans affairs hospitals
Gilmore AK, Davis MT, Grubaugh A, Resnick H, Birks A, Denier C, Muzzy W, Tuerk P, Acierno R. “Do you expect me to receive PTSD care in a setting where most of the other patients remind me of the perpetrator?”: Home-based telemedicine to address barriers to care unique to military sexual trauma and veterans affairs hospitals. Contemporary Clinical Trials 2016, 48: 59-64. PMID: 26992740, PMCID: PMC4926870, DOI: 10.1016/j.cct.2016.03.004.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderHome-based telemedicineMilitary sexual traumaFemale veteransProlonged exposureMajority of patientsEvidence-based treatment deliveryVeterans Affairs hospitalEvidence-based therapiesVA Medical CenterSexual traumaTreat analysisPTSD careHBT groupMedical CenterSession attendanceTreatment centersProvider availabilityLife IndexStress disorderLife outcomesTraumaTreatment deliveryLow attritionPatients
2015
The Posttraumatic Stress Disorder Checklist for DSM‐5 (PCL‐5): Development and Initial Psychometric Evaluation
Blevins CA, Weathers FW, Davis MT, Witte TK, Domino JL. The Posttraumatic Stress Disorder Checklist for DSM‐5 (PCL‐5): Development and Initial Psychometric Evaluation. Journal Of Traumatic Stress 2015, 28: 489-498. PMID: 26606250, DOI: 10.1002/jts.22059.Peer-Reviewed Original ResearchConceptsPosttraumatic Stress Disorder ChecklistPCL-5 scoresComparative fit indexPCL-5Initial psychometric evaluationPTSD symptomsTucker-Lewis indexDSM-5Trauma-exposed college studentsSelf-report measuresPsychometric evaluationStrong internal consistencyConfirmatory factor analysisDSM-5 changesTest-retest reliabilityPTSD criteriaStudy 1Study 2Sound measureDiscriminant validityPsychometric propertiesCollege studentsFit indicesAdequate fitSuperior fit
2014
PTSD Symptom Clusters Are Differentially Associated with Components of the Acquired Capability for Suicide
Zuromski KL, Davis MT, Witte TK, Weathers F, Blevins C. PTSD Symptom Clusters Are Differentially Associated with Components of the Acquired Capability for Suicide. Suicide And Life-Threatening Behavior 2014, 44: 682-697. PMID: 24796870, DOI: 10.1111/sltb.12098.Peer-Reviewed Original ResearchConceptsPTSD symptom clustersPosttraumatic stress disorderAcquired CapabilitySpecific PTSD symptom clustersSymptom clustersTrauma-exposed undergraduatesInterpersonal-psychological theorySuicidal behaviorAnxious arousalPTSD symptomsStress disorderPain tolerancePrevious researchCurrent studySuicideNumbingObserved relationshipArousalRelationshipUndergraduatesConstructsBehaviorDisordersResearchSymptoms