2024
Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia.
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedonia
2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterations
2014
PTSD Symptom Clusters Are Differentially Associated with Components of the Acquired Capability for Suicide
Zuromski KL, Davis MT, Witte TK, Weathers F, Blevins C. PTSD Symptom Clusters Are Differentially Associated with Components of the Acquired Capability for Suicide. Suicide And Life-Threatening Behavior 2014, 44: 682-697. PMID: 24796870, DOI: 10.1111/sltb.12098.Peer-Reviewed Original ResearchConceptsPTSD symptom clustersPosttraumatic stress disorderAcquired CapabilitySpecific PTSD symptom clustersSymptom clustersTrauma-exposed undergraduatesInterpersonal-psychological theorySuicidal behaviorAnxious arousalPTSD symptomsStress disorderPain tolerancePrevious researchCurrent studySuicideNumbingObserved relationshipArousalRelationshipUndergraduatesConstructsBehaviorDisordersResearchSymptoms