2019
Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET
Holmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.Peer-Reviewed Original ResearchConceptsEffects of ketamineKetamine infusionGlutamate transmissionMetabotropic glutamate receptor 5Ketamine-induced effectsKetamine-induced changesGlutamate receptor 5Promising treatment targetDrug challenge studiesTwo-tissue compartment modelMGluR5 radioligandBlood pressureMGluR5 availabilityBaseline scanOutcome measuresHealthy subjectsHeart ratePsychiatric disordersReceptor 5Modulatory effectsMGluR5Treatment targetsChallenge studiesArterial input functionChallenge paradigm
2012
Long-Acting Methylphenidate Reduces Collision Rates of Young Adult Drivers With Attention-Deficit/Hyperactivity Disorder
Cox DJ, Davis M, Mikami AY, Singh H, Merkel RL, Burket R. Long-Acting Methylphenidate Reduces Collision Rates of Young Adult Drivers With Attention-Deficit/Hyperactivity Disorder. Journal Of Clinical Psychopharmacology 2012, 32: 225-230. PMID: 22367664, DOI: 10.1097/jcp.0b013e3182496dc5.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdolescentAttention Deficit Disorder with HyperactivityAutomobile DrivingCentral Nervous System StimulantsCross-Over StudiesDelayed-Action PreparationsFemaleHumansMaleMethylphenidatePsychiatric Status Rating ScalesPsychometricsRisk-TakingTreatment OutcomeVideo RecordingYoung AdultConceptsAttention-deficit/hyperactivity disorderBlood pressureMedication conditionADHD medicationHeart rateBody weightYoung adultsHyperactivity disorderSignificant skin reactionsTotal ADHDMinimal adverse effectsConners' Adult ADHD Rating ScaleSignificant comorbiditiesYoung adult driversADHD Rating ScaleSkin reactionsAdult ADHD Rating ScaleInclusion criteriaAdult driversMTS patchesTransdermal systemRating ScaleAdverse effectsMethylphenidateADHD diagnosis