2016
Continuation Rate of Atypical Antipsychotics After Discharge When Initiated in the Intensive Care Unit
Farrokh S, Castle AC, Heavner M, Pisani MA. Continuation Rate of Atypical Antipsychotics After Discharge When Initiated in the Intensive Care Unit. Journal Of Pharmacy Practice 2016, 30: 342-346. PMID: 27129913, DOI: 10.1177/0897190016645026.Peer-Reviewed Original ResearchConceptsIntensive care unitAtypical antipsychoticsHospital dischargeCare unitSafety outcomesLarge tertiary academic medical centerTertiary academic medical centerFinal study populationAcademic medical centerICU stayLack of evidenceCritical illnessMedical chartsQTc prolongationExtended therapyContinuation ratesInappropriate continuationMedical CenterStudy populationAntipsychoticsExclusion criteriaPhysician documentationPatientsProgress notesOutcomes
2015
Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans
Attia EF, McGinnis KA, Feemster LC, Akgün KM, Butt AA, Graber CJ, Fine MJ, Goetz MB, Rodriguez-Barradas MC, Pisani MA, Tindle HA, Brown ST, Hoo G, Rimland D, Gibert CL, Huang L, Freiberg MS, Hough CL, Crothers K. Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: 280-288. PMID: 26181820, PMCID: PMC4607625, DOI: 10.1097/qai.0000000000000751.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCommunity-acquired pneumoniaPneumocystis jirovecii pneumoniaIndependent risk factorIncidence rate ratiosPulmonary infectionRisk factorsAssociation of COPDBurden of COPDVeterans Aging Cohort Study Virtual CohortRisk of CAPMultivariable Poisson regression modelsBaseline comorbid conditionsDifferent pulmonary infectionsInfections Requiring HospitalizationCD4 cell countHIV viral loadChronic lung diseaseObstructive pulmonary diseaseMultivariable Poisson regressionUnadjusted incidence rateNinth Revision codesPoisson regression modelsJirovecii pneumoniaPulmonary tuberculosisAssociation of Cumulative Dose of Haloperidol With Next-Day Delirium in Older Medical ICU Patients*
Pisani MA, Araujo KL, Murphy TE. Association of Cumulative Dose of Haloperidol With Next-Day Delirium in Older Medical ICU Patients*. Critical Care Medicine 2015, 43: 996-1002. PMID: 25746748, PMCID: PMC4400211, DOI: 10.1097/ccm.0000000000000863.Peer-Reviewed Original ResearchConceptsMedical ICU patientsNext-day deliriumTime-dependent confoundingICU patientsCumulative doseMedical ICUNonintubated patientsOdds ratioConfusion Assessment MethodTreatment of deliriumDose of haloperidolAge 60 yearsEfficacy of haloperidolRoute of administrationAcademic medical centerImportant clinical covariatesICU stayIntubated patientsClinical covariatesObservational studyHigher oddsMedical CenterDeliriumPatientsHaloperidolFunctional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilationSleep in the Intensive Care Unit
Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF. Sleep in the Intensive Care Unit. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 731-738. PMID: 25594808, PMCID: PMC5447310, DOI: 10.1164/rccm.201411-2099ci.Peer-Reviewed Original ResearchConceptsCritical illnessIntensive care unit patientsConcise clinical reviewCare unit patientsIntensive care unitPatient care activitiesCircadian rhythm abnormalitiesCircadian rhythmImportant physiologic processesLack of sleepUnit patientsICU patientsPatients' sleepCare unitClinical reviewAdverse outcomesSleep disturbancesRhythm abnormalitiesRole sleepCare activitiesIllnessClinical researchSleepPatientsPhysiologic processes
2013
The Safety of Thoracentesis in Patients with Uncorrected Bleeding Risk
Puchalski JT, Argento AC, Murphy TE, Araujo KL, Pisani MA. The Safety of Thoracentesis in Patients with Uncorrected Bleeding Risk. Annals Of The American Thoracic Society 2013, 10: 336-341. PMID: 23952852, PMCID: PMC3960907, DOI: 10.1513/annalsats.201210-088oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsBlood Coagulation DisordersClopidogrelCohort StudiesDrainageFemaleHepatic InsufficiencyHumansInternational Normalized RatioMaleMiddle AgedPlatelet Aggregation InhibitorsPleural EffusionPostoperative HemorrhageProspective StudiesRenal Insufficiency, ChronicRisk FactorsThrombocytopeniaTiclopidineWarfarinConceptsBleeding riskHematocrit levelsProspective observational cohort studySafety of thoracentesisWithholding of medicationsObservational cohort studyPotential bleeding riskElevated INRCohort studyRenal diseaseCommon etiologyPleural effusionRisk factorsObservational studyPatientsThoracentesisMedicationsHemothoraxTransfusionSignificant differencesRiskDiseasePhysiological factorsPhysiological parametersSafetyRisk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans
Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 62: 52-59. PMID: 23111572, PMCID: PMC4182723, DOI: 10.1097/qai.0b013e318278f3fa.Peer-Reviewed Original ResearchConceptsVACS Index scoreMedical intensive care unit admissionIntensive care unit admissionVeterans Aging Cohort StudyCare unit admissionMICU admissionIndex scoreRisk factorsHazardous alcohol useVACS IndexUnit admissionCurrent smokingChronic obstructive pulmonary diseaseAlcohol useNon-AIDS diseasesVA administrative databasesMultivariable Cox regressionSurvival of HIVObstructive pulmonary diseaseAging Cohort StudyElectronic medical recordsAntiretroviral therapyCause mortalityPrior AIDSPrior cancer
2012
ICU delirium
Jones SF, Pisani MA. ICU delirium. Current Opinion In Critical Care 2012, 18: 146-151. PMID: 22322260, DOI: 10.1097/mcc.0b013e32835132b9.Peer-Reviewed Original ResearchConceptsICU deliriumRisk factorsLong-term neurocognitive impairmentDelirium-related outcomesPreferred pharmacologic treatmentSignificant adverse outcomesUse of sedativesUse of protocolsPharmacologic treatmentAtypical antipsychoticsVentilator managementAdverse outcomesUnderdiagnosed problemDeliriumNeurocognitive impairmentSusceptible individualsAvailable evidenceRecent evidenceOutcomesLong-term impactTreatmentLimited studiesRobust evidenceNegative outcomesManagementEpidemiology and Management of Common Pulmonary Diseases in Older Persons
Akgün KM, Crothers K, Pisani M. Epidemiology and Management of Common Pulmonary Diseases in Older Persons. The Journals Of Gerontology Series A 2012, 67A: 276-291. PMID: 22337938, PMCID: PMC3297767, DOI: 10.1093/gerona/glr251.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAgedAged, 80 and overAnti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsAsthmaFemaleHumansIdiopathic Pulmonary FibrosisIncidenceLung DiseasesLung NeoplasmsMalePneumoniaPrevalencePulmonary Disease, Chronic ObstructiveRisk FactorsTreatment OutcomeConceptsOlder patientsPulmonary diseaseCommon pulmonary diseasesQuality of lifePulmonary symptomsChronic obstructive pulmonary diseaseCommon clinical presentationObstructive pulmonary diseaseIdiopathic pulmonary fibrosisCommon pulmonary disordersMedical comorbiditiesClinical presentationPulmonary fibrosisLung cancerMultiple etiologiesPulmonary disordersRisk factorsPrevalence increasesDisease prevalence increasesPatientsOlder personsDiseaseMortalityDyspneaComorbidities
2011
Critical Illness in HIV-Infected Patients in the Era of Combination Antiretroviral Therapy
Akgün KM, Huang L, Morris A, Justice AC, Pisani M, Crothers K. Critical Illness in HIV-Infected Patients in the Era of Combination Antiretroviral Therapy. Annals Of The American Thoracic Society 2011, 8: 301-307. PMID: 21653532, PMCID: PMC3132789, DOI: 10.1513/pats.201009-060wr.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAntiretroviral therapyICU admissionCritical illnessAdministration of ARTImpact of ARTProportion of deathsHIV eraOpportunistic infectionsHIVAIDS epidemicMore recent studiesIllnessPatientsAdmissionTherapyRecent studiesICUEtiologyInfectionMortalityIncidenceDiseaseAdministrationThe Changing Epidemiology of HIV-Infected Patients in the Intensive Care Unit
Akgün KM, Pisani M, Crothers K. The Changing Epidemiology of HIV-Infected Patients in the Intensive Care Unit. Journal Of Intensive Care Medicine 2011, 26: 151-164. PMID: 21436170, DOI: 10.1177/0885066610387996.Peer-Reviewed Original ResearchConceptsPneumocystis jirovecii pneumoniaImpact of HAARTICU admissionRespiratory failureIntensive care unit admissionOutcome of HIVActive antiretroviral therapyCare unit admissionLow serum albuminPoor functional statusInflammatory response syndromeIntensive care unitHAART administrationHAART initiationHospital mortalityMedication toxicityUnit admissionAntiretroviral therapyICU mortalityICU survivalComorbid diseasesHIV diagnosisJirovecii pneumoniaCommon indicationResponse syndrome
2010
Factors associated with persistent delirium after intensive care unit admission in an older medical patient population
Pisani MA, Murphy TE, Araujo KL, Van Ness PH. Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. Journal Of Critical Care 2010, 25: 540.e1-540.e7. PMID: 20413252, PMCID: PMC2939229, DOI: 10.1016/j.jcrc.2010.02.009.Peer-Reviewed Original ResearchConceptsPersistent deliriumMedical intensive care unit populationIntensive care unit admissionIntensive care unit populationMultivariable logistic regression modelCare unit admissionConfusion Assessment MethodPatients 60 yearsProspective cohort studyUse of haloperidolUse of opioidsSeverity of illnessMedical patient populationLogistic regression modelsICU stayUnit admissionICU deliriumCohort studyPatient demographicsMedication dataPatient populationConsecutive admissionsCode statusDeliriumUnit population
2009
Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population
Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population. American Journal Of Respiratory And Critical Care Medicine 2009, 180: 1092-1097. PMID: 19745202, PMCID: PMC2784414, DOI: 10.1164/rccm.200904-0537oc.Peer-Reviewed Original ResearchConceptsICU deliriumPatient populationNumber of daysOlder intensive care unit patientsIntensive care unit populationAdverse long-term outcomesIntensive care unit patientsRelevant covariatesUrban acute care hospitalDuration of deliriumPost-ICU admissionConfusion Assessment MethodOlder patient populationProspective cohort studyCare unit patientsSeverity of illnessLong-term outcomesDays of deliriumPsychoactive medication useAcute care hospitalsChart review methodImportant health outcomesICU admissionCohort studyICU population
2008
Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient
Pisani MA. Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient. Journal Of Intensive Care Medicine 2008, 24: 83-95. PMID: 19114416, DOI: 10.1177/0885066608329942.Peer-Reviewed Original ResearchConceptsOlder patientsPhysiologic changesOlder intensive care unit patientsIntensive care unit admissionIntensive care unit patientsIll Older PatientsImportant physiologic changesOlder ICU patientsCare unit admissionCare unit patientsDevelopment of sepsisSeverity of illnessUnit admissionCritical illnessUnit patientsICU patientsPoor outcomeAdverse outcomesRisk factorsCritical careOutcome studiesChronologic agePatientsAge 65Sepsis
2007
The use of missingness screens in clinical epidemiologic research has implications for regression modeling
Van Ness PH, Murphy TE, Araujo KL, Pisani MA, Allore HG. The use of missingness screens in clinical epidemiologic research has implications for regression modeling. Journal Of Clinical Epidemiology 2007, 60: 1239-1245. PMID: 17998078, PMCID: PMC2443713, DOI: 10.1016/j.jclinepi.2007.03.006.Peer-Reviewed Original Research
2003
Cognitive impairment in the intensive care unit
Pisani MA, McNicoll L, Inouye SK. Cognitive impairment in the intensive care unit. Clinics In Chest Medicine 2003, 24: 727-737. PMID: 14710700, DOI: 10.1016/s0272-5231(03)00092-3.Peer-Reviewed Original ResearchMeSH KeywordsCognition DisordersCritical IllnessDeliriumDementiaHumansIntensive Care UnitsRisk FactorsConceptsPre-existing cognitive impairmentCognitive impairmentICU stayICU settingRisk factorsPost-ICU stayRate of deliriumDevelopment of deliriumIntensive care unitPsychoactive medication usePersistence of deliriumDelirium preventionDelirium ratesMedical ICUOlder patientsFrequent complicationMedication useCare unitHigh prevalenceDeliriumICUOlder personsStayImpairmentPatients