2024
Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial
Mart M, Boehm L, Kiehl A, Gong M, Malhotra A, Owens R, Khan B, Pisani M, Schmidt G, Hite R, Exline M, Carson S, Hough C, Rock P, Douglas I, Feinstein D, Hyzy R, Schweickert W, Bowton D, Masica A, Orun O, Raman R, Pun B, Strength C, Rolfsen M, Pandharipande P, Brummel N, Hughes C, Patel M, Stollings J, Ely E, Jackson J, Girard T. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine 2024, 12: 599-607. PMID: 38701817, PMCID: PMC11296889, DOI: 10.1016/s2213-2600(24)00077-8.Peer-Reviewed Original ResearchEffects of antipsychotic treatmentCognitive impairmentAssociated with long-term cognitive impairmentTreat deliriumLong-term cognitive impairmentLong-term outcomesTreatment of deliriumCritically ill patientsAntipsychotic treatmentZiprasidone groupHaloperidol groupFollow-upQuality-of-life outcomesAssessed survivorsZiprasidoneHaloperidolAntipsychoticsCognitive outcomesTreatment group assignmentDepartment of Veterans AffairsQuality-of-lifeIll patientsPlacebo-controlledCritical illnessLong-term follow-up
2016
Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers
Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.Peer-Reviewed Original ResearchConceptsPoor sleepICU outcomesProviders' perceptionsIntensive care unit outcomesAvailable evidence-based guidelinesDevelopment of deliriumIntensive care unitEvidence-based guidelinesCritical care providersBetter sleep qualityMinority of providersICU surveyICU patientsIll patientsCare unitMechanical ventilationICU providersPatient outcomesRecent guidelinesPhysical therapyMost cliniciansPromotion protocolSleep qualityCare providersICU
2015
Sedation in Critically Ill Patients
Oldham M, Pisani MA. Sedation in Critically Ill Patients. Critical Care Clinics 2015, 31: 563-587. PMID: 26118921, DOI: 10.1016/j.ccc.2015.03.010.Peer-Reviewed Original ResearchSleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit
Knauert MP, Haspel JA, Pisani MA. Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 419-429. PMID: 26304279, DOI: 10.1016/j.ccm.2015.05.008.BooksConceptsCritical illnessSleep disruptionAppropriate administrative supportIntensive care unit environmentIntensive care unitCircadian rhythm disruptionDelirium reductionIll patientsCare unitPharmacologic interventionsSleep disturbancesRhythm disruptionCare deliveryMultidisciplinary strategyUnit environmentSleep lossIllnessDisruptionPatientsEffective strategySleepEnvironmental factors
2014
Feasibility study of unattended polysomnography in medical intensive care unit patients
Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart & Lung 2014, 43: 445-452. PMID: 25023504, PMCID: PMC4150840, DOI: 10.1016/j.hrtlng.2014.06.049.Peer-Reviewed Original ResearchConceptsMedical intensive care unitPortable polysomnographySleep efficiencyMedical intensive care unit patientsIntensive care unit patientsSleep deprivationOvernight sleep durationCare unit patientsObservational pilot studyIntensive care unitIndicators of feasibilityUnattended polysomnographyUnit patientsIll patientsPatients' sleepCare unitArousal indexPSG studiesSleep durationPatientsInterpretable qualityPilot studyGold standardSleepSleep stages
2012
156
Mathews K, Jenq G, Siner J, Long E, Pisani M. 156. Critical Care Medicine 2012, 40: 1-328. DOI: 10.1097/01.ccm.0000424376.53968.a1.Peer-Reviewed Original ResearchICU admissionIntermediate care unitEmergency departmentIll patientsCare unitYale-New Haven HospitalICU resource utilizationICU-level interventionsRegular medical wardRetrospective chart reviewICU adult patientsLife-saving interventionsICU arrivalICU censusICU workloadSCCM guidelinesHospital courseAdult patientsChart reviewLonger admissionsICU patientsMedical wardsICU providersHigh percentageDiagnostic guidelines
2008
Delirium assessment in the intensive care unit: patient population matters
Pisani MA. Delirium assessment in the intensive care unit: patient population matters. Critical Care 2008, 12: 131. PMID: 18423059, PMCID: PMC2447584, DOI: 10.1186/cc6847.Peer-Reviewed Original Research