2016
Dexmedetomidine for hyperactive delirium: worth further study
Knauert MP, Pisani MA. Dexmedetomidine for hyperactive delirium: worth further study. Journal Of Thoracic Disease 2016, 8: e999-e1002. PMID: 27747045, PMCID: PMC5059358, DOI: 10.21037/jtd.2016.08.14.Commentaries, Editorials and LettersRisk factorsIntensive care unit patientsLength of ICUHistory of hypertensionCare unit patientsManagement of painPre-existing dementiaSeverity of illnessClinical practice guidelinesCritical care issuesHigher healthcare costsHistory of alcoholismLong-term cognitionPoor ICU outcomesCritical care medicineICU incidenceICU medicationsIntravenous haloperidolHospital stayHyperactive deliriumICU deliriumAdult patientsUnit patientsMechanical ventilationICU outcomes
2012
ICU delirium
Jones SF, Pisani MA. ICU delirium. Current Opinion In Critical Care 2012, 18: 146-151. PMID: 22322260, DOI: 10.1097/mcc.0b013e32835132b9.Peer-Reviewed Original ResearchConceptsICU deliriumRisk factorsLong-term neurocognitive impairmentDelirium-related outcomesPreferred pharmacologic treatmentSignificant adverse outcomesUse of sedativesUse of protocolsPharmacologic treatmentAtypical antipsychoticsVentilator managementAdverse outcomesUnderdiagnosed problemDeliriumNeurocognitive impairmentSusceptible individualsAvailable evidenceRecent evidenceOutcomesLong-term impactTreatmentLimited studiesRobust evidenceNegative outcomesManagement
2010
Factors associated with persistent delirium after intensive care unit admission in an older medical patient population
Pisani MA, Murphy TE, Araujo KL, Van Ness PH. Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. Journal Of Critical Care 2010, 25: 540.e1-540.e7. PMID: 20413252, PMCID: PMC2939229, DOI: 10.1016/j.jcrc.2010.02.009.Peer-Reviewed Original ResearchConceptsPersistent deliriumMedical intensive care unit populationIntensive care unit admissionIntensive care unit populationMultivariable logistic regression modelCare unit admissionConfusion Assessment MethodPatients 60 yearsProspective cohort studyUse of haloperidolUse of opioidsSeverity of illnessMedical patient populationLogistic regression modelsICU stayUnit admissionICU deliriumCohort studyPatient demographicsMedication dataPatient populationConsecutive admissionsCode statusDeliriumUnit population
2009
Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population
Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of Delirium Are Associated with 1-Year Mortality in an Older Intensive Care Unit Population. American Journal Of Respiratory And Critical Care Medicine 2009, 180: 1092-1097. PMID: 19745202, PMCID: PMC2784414, DOI: 10.1164/rccm.200904-0537oc.Peer-Reviewed Original ResearchConceptsICU deliriumPatient populationNumber of daysOlder intensive care unit patientsIntensive care unit populationAdverse long-term outcomesIntensive care unit patientsRelevant covariatesUrban acute care hospitalDuration of deliriumPost-ICU admissionConfusion Assessment MethodOlder patient populationProspective cohort studyCare unit patientsSeverity of illnessLong-term outcomesDays of deliriumPsychoactive medication useAcute care hospitalsChart review methodImportant health outcomesICU admissionCohort studyICU populationBenzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*
Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population*. Critical Care Medicine 2009, 37: 177-183. PMID: 19050611, PMCID: PMC2700732, DOI: 10.1097/ccm.0b013e318192fcf9.Peer-Reviewed Original ResearchConceptsModifiable risk factorsICU deliriumDelirium durationOpioid useRisk factorsFirst episodeMedical intensive care unit patientsIntensive care unit deliriumMedical intensive care unitIntensive care unit patientsUrban university teaching hospitalConfusion Assessment MethodProspective cohort studyCare unit patientsSeverity of illnessIntensive care unitUniversity Teaching HospitalMain outcome measuresUse of benzodiazepinesChart review methodMultivariable regression modelsImpact of benzodiazepinesCohort studyMedian durationUnit patients
2007
Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit
Pisani MA, Murphy TE, Van Ness PH, Araujo KL, Inouye SK. Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit. JAMA Internal Medicine 2007, 167: 1629-1634. PMID: 17698685, DOI: 10.1001/archinte.167.15.1629.Peer-Reviewed Original ResearchConceptsAdmission risk factorsMedical record reviewIntensive care unitICU admissionRisk factorsOlder patientsRecord reviewCare unitMedical intensive care unitUrban university teaching hospitalOlder ICU patientsReceipt of benzodiazepinesConfusion Assessment MethodPatients 60 yearsProspective cohort studyLower arterial pHUniversity Teaching HospitalMain outcome measuresMultivariate logistic regressionDelirium durationICU deliriumCohort studyCreatinine levelsICU patientsArterial pH