Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments
Orias M, Velázquez H, Tung F, Lee G, Desir G. Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. American Journal Of Physiology 1997, 273: f663-f666. PMID: 9362344, DOI: 10.1152/ajprenal.1997.273.4.f663.Peer-Reviewed Original ResearchConceptsThick ascending limbAscending limbK channelsCortical thick ascending limbMedullary thick ascending limbDistal nephron segmentsReverse transcription-polymerase chain reactionDistal convoluted tubuleTranscription-polymerase chain reactionDistal tubulesConvoluted tubulesProximal tubulesNephron segmentsHigh expressionNephron segment localizationK homeostasisChain reactionHuman kidney cDNATubulesSegment localizationExclusive expressionKCNK1LimbPore regionKidney cDNAGenomic Localization of the Human Gene for KCNA10, a cGMP-Activated K Channel
Orias M, Bray-Ward P, Curran M, Keating M, Desir G. Genomic Localization of the Human Gene for KCNA10, a cGMP-Activated K Channel. Genomics 1997, 42: 33-37. PMID: 9177773, DOI: 10.1006/geno.1997.4712.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceChromosome MappingChromosomes, Artificial, YeastChromosomes, Human, Pair 1Cloning, MolecularCyclic GMPDNA PrimersHumansIn Situ Hybridization, FluorescenceMicrosatellite RepeatsMolecular Sequence DataPolymerase Chain ReactionPotassium ChannelsPotassium Channels, Voltage-GatedShaker Superfamily of Potassium ChannelsConceptsHuman genesK channel genesCandidate gene analysisGenomic localizationMicrosatellite lociCellular functionsGenetic intervalYAC clonesChromosome 1Channel genesFiner mappingGenesKCNA10Gene analysisSitu hybridizationK channelsCritical rolePotassium channelsIntracellular cGMPP13.1KCNA3CGMPImportant componentLociClones