2024
Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?
Grajales-Reyes JG, Chen B, Meseguer D, Schneeberger M. Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation? Physiology (Bethesda) 2024, 39: 0. PMID: 38536114, DOI: 10.1152/physiol.00034.2023.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNeuro-Adipokine Crosstalk in Alzheimer’s Disease
Chen, B.; Schneeberger, M. Neuro-Adipokine Crosstalk in Alzheimer’s Disease. Int. J. Mol. Sci. 2024, 25, 5932.Peer-Reviewed Original ResearchMaternal nutritional programming shapes the cerebral landscape.
Chen B, de Launoit E, Renier N, Schneeberger M. Maternal nutritional programming shapes the cerebral landscape. Trends Endocrinol Metab 2024, 35: 367-370. PMID: 37949733, DOI: 10.1016/j.tem.2023.10.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCentral myelin dysfunction bridges obesity and neurological diseases.
Chen B, de Launoit E, Renier N, Schneeberger M. Central myelin dysfunction bridges obesity and neurological diseases. Trends Endocrinol Metab 2024, 35: 7-10. PMID: 37798242, DOI: 10.1016/j.tem.2023.09.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2023
Dynamic rewiring of neurovasculature in health and disease.
Chen B, Meseguer D, Renier N, Schneeberger M. Dynamic rewiring of neurovasculature in health and disease. Trends Mol Med 2023, 29: 786-788. PMID: 37487781, DOI: 10.1016/j.molmed.2023.06.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system.
Choi M, Schneeberger M, Fan W, Bugde A, Gautron L, Vale K, Hammer RE, Zhang Y, Friedman JM, Mangelsdorf DJ, Kliewer SA. FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system. Cell Metab 2023, 35: 429-437.e5. PMID: 36889282, DOI: 10.1016/j.cmet.2023.02.005.Peer-Reviewed Original Research
2022
Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction.
Schneeberger M, Brice NL, Pellegrino K, Parolari L, Shaked JT, Page KJ, Marchildon F, Barrows DW, Carroll TS, Topilko T, Mulligan VM, Newman R, Doyle K, Bürli R, Barker DF, Glen A, Ortuño MJ, Nectow AR, Renier N, Cohen P, Carlton M, Heintz N, Friedman JM. Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction. Nat Metab 2022, 4: 1495-1513. PMID: 36411386, DOI: 10.1038/s42255-022-00677-8.Peer-Reviewed Original ResearchRemission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.
Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM. Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. Redox Biol 2022, 54: 102353. PMID: 35777200, DOI: 10.1016/j.redox.2022.102353.Peer-Reviewed Original Research
2021
Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure.
Ortuño MJ, Schneeberger M, Ilanges A, Marchildon F, Pellegrino K, Friedman JM, Ducy P. Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure. The Journal Of Clinical Investigation 2021, 131 PMID: 34673574, PMCID: PMC8670849, DOI: 10.1172/JCI151976.Peer-Reviewed Original ResearchMultifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis.
Al-Massadi O, Dieguez C, Schneeberger M, López M, Schwaninger M, Prevot V, Nogueiras R. Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis. Nature Reviews. Endocrinology 2021, 17: 745-755. PMID: 34608277, DOI: 10.1038/s41574-021-00559-1.Peer-Reviewed Original ResearchFunctional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice.
Parolari L, Schneeberger M, Heintz N, Friedman JM. Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice. Molecular Psychiatry 2021, 26: 7029-7046. PMID: 34099874, DOI: 10.1038/s41380-021-01162-6.Peer-Reviewed Original ResearchMitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis
Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D’Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M. Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis. Cell Metabolism 2021, 33: 1820-1835.e9. PMID: 34343501, PMCID: PMC8432968, DOI: 10.1016/j.cmet.2021.07.008.Peer-Reviewed Original ResearchConceptsProtein OPA1Mitochondrial CaMitochondrial cristae architectureAdipose tissue lipolysisKey metabolic sensorPOMC neuronsCellular metabolic adaptationTissue lipolysisCristae architectureMetabolic sensorNutrient availabilityWhite adipose tissue lipolysisAlpha-melanocyte stimulating hormoneGenetic inactivationNovel axisMitochondrial functionOPA1Metabolic adaptationMitochondrial cristaeDramatic alterationsMutant miceProopiomelanocortin neuronsLipolysis controlWAT lipolysisPharmacological blockadeCritical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues.
Ito K, Schneeberger M, Gerber A, Jishage M, Marchildon F, Maganti AV, Cohen P, Friedman JM, Roeder RG. Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues. Genes & Development 2021, 35: 729-748. PMID: 33888560, PMCID: PMC8091968, DOI: 10.1101/gad.346791.120.Peer-Reviewed Original Research
2020
Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose.
Muller PA, Matheis F, Schneeberger M, Kerner Z, Jové V, Mucida D. Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose. Science (New York, N.Y.) 2020, 370: 314-321. PMID: 32855216, PMCID: PMC7886298, DOI: 10.1126/science.abd6176.Peer-Reviewed Original ResearchA limbic circuit selectively links active escape to food suppression.
Azevedo EP, Tan B, Pomeranz LE, Ivan V, Fetcho R, Schneeberger M, Doerig KR, Liston C, Friedman JM, Stern SA. A limbic circuit selectively links active escape to food suppression. ELife 2020, 9 PMID: 32894221, PMCID: PMC7476759, DOI: 10.7554/eLife.58894.Peer-Reviewed Original ResearchAuthor Correction: Microbiota modulate sympathetic neurons via a gut-brain circuit.
Muller PA, Schneeberger M, Matheis F, Wang P, Kerner Z, Ilanges A, Pellegrino K, Del Mármol J, Castro TBR, Furuichi M, Perkins M, Han W, Rao A, Pickard AJ, Cross JR, Honda K, de Araujo I, Mucida D. Author Correction: Microbiota modulate sympathetic neurons via a gut-brain circuit. Nature 2020, 585: E2. PMID: 32814907, DOI: 10.1038/s41586-020-2657-2.Peer-Reviewed Original ResearchA leptin-BDNF pathway regulating sympathetic innervation of adipose tissue.
Wang P, Loh KH, Wu M, Morgan DA, Schneeberger M, Yu X, Chi J, Kosse C, Kim D, Rahmouni K, Cohen P, Friedman J. A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue. Nature 2020, 583: 839-844. PMID: 32699414, DOI: 10.1038/s41586-020-2527-y.Peer-Reviewed Original Research
2019
Regulation of Energy Expenditure by Brainstem GABA Neurons.
Schneeberger M, Parolari L, Das Banerjee T, Bhave V, Wang P, Patel B, Topilko T, Wu Z, Choi CHJ, Yu X, Pellegrino K, Engel EA, Cohen P, Renier N, Friedman JM, Nectow AR. Regulation of Energy Expenditure by Brainstem GABA Neurons. Cell 2019, 178: 672-685.e12. PMID: 31257028, PMCID: PMC7481042, DOI: 10.1016/j.cell.2019.05.048.Peer-Reviewed Original ResearchA Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake.
Azevedo EP, Pomeranz L, Cheng J, Schneeberger M, Vaughan R, Stern SA, Tan B, Doerig K, Greengard P, Friedman JM. A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake. Neuron 2019, 102: 873-886.e5. PMID: 30930044, DOI: 10.1016/j.neuron.2019.03.011.Peer-Reviewed Original ResearchIrx3, a new leader on obesity genetics.
Schneeberger M. Irx3, a new leader on obesity genetics. EBioMedicine 2019, 39: 19-20. PMID: 30541683, PMCID: PMC6354703, DOI: 10.1016/j.ebiom.2018.12.005.Peer-Reviewed Original Research