The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review
Greenberg N, Farhadi F, Kazer B, Potenza M, Angarita G. The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review. Current Addiction Reports 2022, 9: 660-670. PMID: 38362235, PMCID: PMC10868722, DOI: 10.1007/s40429-022-00446-3.Peer-Reviewed Original ResearchN-acetylcysteineSelf-injurious behaviorEffectiveness of NACEfficacy of NACSmall open-label trialsUse of NACCompulsive sexual behaviorOpen-label trialRepetitive self-injurious behaviorSexual behaviorCompulsive behaviorsGambling disorderGlutamate dysregulationBehavioral addictionsCase reportClinical trialsPreclinical studiesGlutamate homeostasisAcetyl cysteineDisordersMore studiesScoping ReviewCompulsive featuresAddictionImpulsive behaviorMechanistic Effects and Use of N-acetylcysteine in Substance Use Disorders
Greenberg N, Farhadi F, Kazer B, Potenza M, Angarita G. Mechanistic Effects and Use of N-acetylcysteine in Substance Use Disorders. Current Behavioral Neuroscience Reports 2022, 9: 124-143. DOI: 10.1007/s40473-022-00250-3.Peer-Reviewed Original ResearchSubstance use disordersN-acetylcysteineUse disordersEfficacy of NACTreatment of SUDsGlial glutamate transporter-1Glutamate transporter 1Drug-seeking behaviorCue-induced reinstatementNAC useAdjunctive useClinical studiesGlutamate homeostasisGlutamate signalingNeurobiological effectsClinical approachRelapse behaviorSubcortical regionsSynaptic plasticityFunctional connectivity networksPrefrontal cortexBehavioral interventionsTransporter 1Oxidative stressImpulsive behavior