2021
Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2
Yuan G, Guehl N, Zheng B, Qu X, Moon S, Dhaynaut M, Shoup T, Afshar S, Kang H, Zhang Z, El Fakhri G, Normandin M, Brownell A. Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. Molecular Imaging And Biology 2021, 23: 527-536. PMID: 33559035, PMCID: PMC8277681, DOI: 10.1007/s11307-021-01586-0.Peer-Reviewed Original ResearchConceptsNon-human primatesIn vivo PET imaging studiesNucleus accumbensGlutamate receptor 2PET imaging ligandsImaging ligandsParietal cortexBrain regionsPET imaging studiesPET radioligandIn vivo PET imaging experimentsVolume of distributionMGluR2C57BL/6 J micePET imaging experimentsPET studiesBrainSprague-Dawley ratsAlzheimer's diseaseBrain permeabilityPre-treatment studyImaging studiesDisordersRat studiesReversible kinetics
2020
Syntheses of [ 11 C]2- and [ 11 C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases
Ramos-Torres K, Zhou Y, Yang B, Guehl N, Sung-Hyun M, Telu S, Normandin M, Pike V, Brugarolas P. Syntheses of [ 11 C]2- and [ 11 C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases. RSC Medicinal Chemistry 2020, 11: 1161-1167. PMID: 33479620, PMCID: PMC7651860, DOI: 10.1039/d0md00190b.Peer-Reviewed Original ResearchTrifluoromethyl groupPET radioligand