2011
Synthesis and evaluation of [18F]exendin (9–39) as a potential biomarker to measure pancreatic β-cell mass
Wang Y, Lim K, Normandin M, Zhao X, Cline GW, Ding YS. Synthesis and evaluation of [18F]exendin (9–39) as a potential biomarker to measure pancreatic β-cell mass. Nuclear Medicine And Biology 2011, 39: 167-176. PMID: 22033026, PMCID: PMC4484741, DOI: 10.1016/j.nucmedbio.2011.07.011.Peer-Reviewed Original ResearchConceptsStandardized uptake valuePositron emission tomography (PET) imagingEmission Tomography ImagingPancreatic β-cell massΒ-cell massTomography imagingInsulin contentGlucagon-like peptide-1 (GLP-1) receptor antagonistGlucagon-like peptide-1Biobreeding diabetes-prone (BB-DP) ratDiabetes-prone ratsVivo positron emission tomography (PET) imagingSprague-Dawley ratsBlood glucose homeostasisReceptor antagonistGlucose homeostasisPeptide-1Time-activity curvesUptake valuePotential biomarkersHigh-resolution research tomographExendin analogsIn-111RatsPostmortem measures
2010
Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes
Singhal T, Ding YS, Weinzimmer D, Normandin MD, Labaree D, Ropchan J, Nabulsi N, Lin SF, Skaddan MB, Soeller WC, Huang Y, Carson RE, Treadway JL, Cline GW. Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes. Molecular Imaging And Biology 2010, 13: 973-984. PMID: 20824509, PMCID: PMC3711476, DOI: 10.1007/s11307-010-0406-x.Peer-Reviewed Original Research