2024
Novel multi-modal methodology to investigate placebo response in major depressive disorder
Cusin C, Dillon D, Belleau E, Normandin M, Petibon Y, El-Fakri G, Dhaynaut M, Hooker J, Kaptchuk T, McKee M, Hayden E, Meyer A, Jahan A, Origlio J, Ang Y, Brunner D, Kang M, Long Y, Fava M, Pizzagalli D. Novel multi-modal methodology to investigate placebo response in major depressive disorder. Journal Of Affective Disorders 2024, 368: 1-7. PMID: 39233242, DOI: 10.1016/j.jad.2024.08.226.Peer-Reviewed Original ResearchPlacebo responseDepressive disorderRates of placebo responseMesocorticolimbic dopaminergic pathwayExpectation of rewardAntidepressant responseMesolimbic systemReward circuitryNeurobiological underpinningsNeurobiological mechanismsDopaminergic activityDopaminergic systemPlacebo respondersSymptom reductionDopaminergic pathwaysMulti-modal methodologyPlacebo phenomenonPsychological constructsTreatment developmentMDDPlacebo-controlledClinical trialsDouble-blindRewardDesigning clinical trials
2011
Striatal dopamine transporter availability in unmedicated bipolar disorder
Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng Q, Hutchins G, Normandin M, Yoder K. Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disorders 2011, 13: 406-413. PMID: 21843280, DOI: 10.1111/j.1399-5618.2011.00936.x.Peer-Reviewed Original ResearchConceptsDopamine transporter availabilityBipolar disorderDopamine transporterPositron emission tomographyNeuropathology of bipolar disorderStriatal dopamine transporter availabilityEtiology of bipolar disorderMultilinear reference tissue modelUnmedicated BPD patientsBilateral dorsal caudatePresynaptic dopamine functionStructural magnetic resonance imagingStriatal binding potentialReceptor imaging studiesReference tissue modelMagnetic resonance imagingBPD patientsDopamine functionDopamine neurotransmissionDopamine systemDorsal caudateSynaptic dopamineBPD subjectsDopaminergic systemDepressive phase