2014
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response
Kosmaczewski SG, Edwards TJ, Han SM, Eckwahl MJ, Meyer BI, Peach S, Hesselberth JR, Wolin SL, Hammarlund M. The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. EMBO Reports 2014, 15: 1278-1285. PMID: 25366321, PMCID: PMC4264930, DOI: 10.15252/embr.201439531.Peer-Reviewed Original ResearchConceptsUnfolded protein responseProtein responseRNA ligationIRE-1 branchesMultiple essential processesRNA ligase RtcBXBP-1 mRNACaenorhabditis elegansRNA functionRtcBMRNA fragmentsTarget RNARNA sequencesXBP-1RNA ligaseTRNAEssential processEssential componentMaturationElegansLifespanMutantsLigaseVivo modelXBP1Axon Regeneration Genes Identified by RNAi Screening in C. elegans
Nix P, Hammarlund M, Hauth L, Lachnit M, Jorgensen EM, Bastiani M. Axon Regeneration Genes Identified by RNAi Screening in C. elegans. Journal Of Neuroscience 2014, 34: 629-645. PMID: 24403161, PMCID: PMC3870940, DOI: 10.1523/jneurosci.3859-13.2014.Peer-Reviewed Original ResearchConceptsRNAi-based screenCandidate gene screenAnalysis of mutantsGrowth-inhibiting functionComplex molecular eventsCell-intrinsic factorsCaenorhabditis elegansC. elegansAxon regenerationGene candidatesRNAi screeningMembrane dynamicsMAP kinaseΒ-spectrinRegeneration genesGene screenMolecular eventsGenesElegansRobust regenerationMature neuronsMutantsMammalian CNSAntagonistic activityPathway
2000
Mutations in β-Spectrin Disrupt Axon Outgrowth and Sarcomere Structure
Hammarlund M, Davis W, Jorgensen E. Mutations in β-Spectrin Disrupt Axon Outgrowth and Sarcomere Structure. Journal Of Cell Biology 2000, 149: 931-942. PMID: 10811832, PMCID: PMC2174563, DOI: 10.1083/jcb.149.4.931.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAxonsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MembraneCell PolarityDNA PrimersDNA, ComplementaryEpithelial CellsGenes, HelminthGenes, ReporterGreen Fluorescent ProteinsIntestinesIntracellular MembranesLuminescent ProteinsMolecular Sequence DataMutationSarcomeresSequence Homology, Amino AcidSpectrinSynaptic VesiclesConceptsCell polarityBeta spectrinMembrane skeletonCell membraneCaenorhabditis elegans homologueMost animal cellsSpecific membrane proteinsMembrane integrityAxon outgrowthNull mutantsMembrane proteinsAnimal cellsAbnormal axon outgrowthPlasma membraneSarcomere structureProteinDense bodiesMembraneOutgrowthMajor componentMyofilament latticeMutantsHomologuesGenesPolarity