2016
Inhibiting poly(ADP-ribosylation) improves axon regeneration
Byrne AB, McWhirter RD, Sekine Y, Strittmatter SM, Miller DM, Hammarlund M. Inhibiting poly(ADP-ribosylation) improves axon regeneration. ELife 2016, 5: e12734. PMID: 27697151, PMCID: PMC5050021, DOI: 10.7554/elife.12734.Peer-Reviewed Original ResearchConceptsNovel intrinsic regulatorAxon regenerationDLK functionChemical inhibitionIntrinsic regulatorRegeneration pathwayPARG expressionIntrinsic regenerative potentialDLK signalingCritical functionsPARGRegenerative potentialPARP inhibitorsProteinPARPMammalian cortical neuronsRegenerationMotor neuronsGABA neuronsPolymeraseCortical neuronsSignalingRegulatorSpeciesNeurons
2014
Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration
Byrne AB, Walradt T, Gardner KE, Hubbert A, Reinke V, Hammarlund M. Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration. Neuron 2014, 81: 561-573. PMID: 24440228, PMCID: PMC3924874, DOI: 10.1016/j.neuron.2013.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsDisease Models, AnimalForkhead Transcription FactorsGene Expression RegulationGreen Fluorescent ProteinsHumansImmunosuppressive AgentsInsulinInsulin-Like Growth Factor INerve DegenerationNerve RegenerationPhosphotransferases (Alcohol Group Acceptor)PTEN PhosphohydrolaseSignal TransductionSirolimusTime FactorsTranscription Factors
2009
Axon Regeneration Requires a Conserved MAP Kinase Pathway
Hammarlund M, Nix P, Hauth L, Jorgensen EM, Bastiani M. Axon Regeneration Requires a Conserved MAP Kinase Pathway. Science 2009, 323: 802-806. PMID: 19164707, PMCID: PMC2729122, DOI: 10.1126/science.1165527.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAxonsAxotomyCaenorhabditis elegansCaenorhabditis elegans ProteinsGamma-Aminobutyric AcidGrowth ConesMAP Kinase Kinase 4MAP Kinase Kinase KinasesMAP Kinase Signaling SystemMitogen-Activated Protein KinasesModels, BiologicalMotor NeuronsMutationNerve RegenerationRNA InterferenceConceptsCell-intrinsic regeneration pathwaysKinase pathwayCaenorhabditis elegans motor neuronsMitogen-activated protein kinase pathwayMAP kinase cascadeMAP kinase pathwayProtein kinase pathwayGrowth cone migrationKinase cascadeRegeneration pathwayCone migrationLater stepsLack of activationDevelopment of therapiesMature neuronsPathwayAplastic statesMost neuronsRegenerationMotor neuronsAxon injuryAxon regenerationNeuron functionActivationNeurons