Binding of FANCD2 to SRSF1 Splicing Factor Prevents Genomic Instability through R Loop Regulation
Olazabal-Herrero A, Green A, Chen X, Sung P, Pillai M, Kupfer G. Binding of FANCD2 to SRSF1 Splicing Factor Prevents Genomic Instability through R Loop Regulation. Blood 2020, 136: 19. DOI: 10.1182/blood-2020-141369.Peer-Reviewed Original ResearchR-loopsFA pathwayGenomic instabilityFanconi anemiaSplicing factorsR-loop metabolismR-loop regulationFA-like phenotypeBasic cellular processesR-loop formationKey regulatory stepNon-canonical roleDNA damaging agentsNon-canonical mechanismFANCD2-FANCIGenome maintenanceFANCD2 monoubiquitinationMRNA exportGenomic sitesCellular processesInsect cellsProcessing proteinsFA phenotypeRNA transcriptionRegulatory step