2019
Knowledge and Practices of Physicians and Nurses Related to Urine Cultures in Catheterized Patients: An Assessment of Adherence to IDSA Guidelines
Advani S, Gao C, Datta R, Sann L, Smith C, Leapman MS, Hittelman A, Sabetta J, Dembry LM, Martinello RA, Juthani-Mehta M. Knowledge and Practices of Physicians and Nurses Related to Urine Cultures in Catheterized Patients: An Assessment of Adherence to IDSA Guidelines. Open Forum Infectious Diseases 2019, 6: ofz305. PMID: 31375836, PMCID: PMC6677670, DOI: 10.1093/ofid/ofz305.Peer-Reviewed Original ResearchCatheter-associated urinary tract infectionsClostridioides difficile infectionUrine cultureChart reviewPractice patternsInitiation of antimicrobialsUrine culture ordersPositive urine cultureInfectious Diseases SocietyUrinary tract infectionAcademic health care systemAbsence of symptomsDrug adverse eventsAssessment of adherencePractices of physiciansHealth care systemOdor of urineIDSA guidelinesCatheterized patientsAdverse eventsDiseases SocietyTract infectionsDifficile infectionUrinary catheterResponse rateIncreased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2018
Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report
Datta R, Advani S, Rink A, Bianco L, Van Ness PH, Quagliarello V, Juthani-Mehta M. Increased Fluoroquinolone-Susceptibility and Preserved Nitrofurantoin-Susceptibility among Escherichia coli Urine Isolates from Women Long-Term Care Residents: A Brief Report. Open Access Journal Of Gerontology & Geriatric Medicine 2018, 4: 555636. PMID: 30465048, PMCID: PMC6241532, DOI: 10.19080/oajggm.2018.04.555636.Peer-Reviewed Original ResearchLong-term care residentsUrinary tract infectionUrine isolatesCare residentsTract infectionsUncomplicated urinary tract infectionsLong-term care facilitiesTrimethoprim/sulfamethoxazoleEmpiric therapyCommon indicationOptimal therapyUrine cultureUrinary isolatesAntimicrobial therapyClinical trialsNitrofurantoin susceptibilityCare facilitiesFluoroquinolone susceptibilityAntimicrobial susceptibilityPredominant organismTherapyInfectionCefazolinIsolatesBacterial isolates
2016
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial
Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA 2016, 316: 1879-1887. PMID: 27787564, PMCID: PMC5300771, DOI: 10.1001/jama.2016.16141.Peer-Reviewed Original ResearchConceptsUrinary tract infectionPresence of bacteriuriaSymptomatic urinary tract infectionCranberry capsulesNursing homesOlder womenTreatment groupsControl groupPlacebo-controlled efficacy trialSignificant differencesRate of deathAntibiotic-resistant organismsControl group participantsCause deathStudy surveillanceCause hospitalizationSecondary outcomesTract infectionsPrimary outcomeOverall adherenceAntimicrobial utilizationClinical trialsEfficacy trialsPyuriaUnadjusted results
2014
A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders
Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders. Clinical Infectious Diseases 2014, 60: 849-857. PMID: 25520333, PMCID: PMC4415071, DOI: 10.1093/cid/ciu935.Peer-Reviewed Original ResearchConceptsNursing home residentsUsual careHome residentsIntervention protocolFirst pneumoniaControl armClinical trialsNursing homesMultivariable Cox regression modelsElderly nursing home residentsCluster-randomized clinical trialImportant public health problemChlorhexidine oral rinseModifiable risk factorsRespiratory tract infectionsCox regression modelNursing home eldersPublic health problemHazard ratioPneumonia preventionSecondary outcomesTract infectionsControlled TrialsPrimary outcomeOral rinseUrinary Tract Infections in Older Women: A Clinical Review
Mody L, Juthani-Mehta M. Urinary Tract Infections in Older Women: A Clinical Review. JAMA 2014, 311: 844-854. PMID: 24570248, PMCID: PMC4194886, DOI: 10.1001/jama.2014.303.Peer-Reviewed Original ResearchConceptsSymptomatic urinary tract infectionRecurrent urinary tract infectionsUrinary tract infectionAsymptomatic bacteriuriaOlder womenTract infectionsUrine cultureRecurrent symptomatic urinary tract infectionsDiagnosis of UTIOlder community-dwelling womenEnglish-language human studiesChronic suppressive antibioticsCostovertebral angle painNegative dipstick resultsSymptomatic UTI episodesVaginal estrogen therapyAdverse effect profilePositive urine cultureLocal resistance ratesCommunity-dwelling womenLow pretest probabilityCareful clinical evaluationClinical diagnostic criteriaSearch of OvidRecent sexual intercourse
2013
Diagnosis and Management of Urinary Tract Infection in Older Adults
Rowe TA, Juthani-Mehta M. Diagnosis and Management of Urinary Tract Infection in Older Adults. Infectious Disease Clinics Of North America 2013, 28: 75-89. PMID: 24484576, PMCID: PMC4079031, DOI: 10.1016/j.idc.2013.10.004.Peer-Reviewed Original ResearchUrinary tract infection in older adults
Rowe TA, Juthani-Mehta M. Urinary tract infection in older adults. Aging Health 2013, 9: 519-528. PMID: 24391677, PMCID: PMC3878051, DOI: 10.2217/ahe.13.38.Peer-Reviewed Original ResearchUrinary tract infectionTract infectionsAsymptomatic bacteriuriaOlder adultsSymptomatic urinary tract infectionLong-term care facilitiesMultidrug-resistant organismsEvidence-based approachGenitourinary symptomsGold standard definitionConsensus guidelinesDiagnostic challengeCare facilitiesInfectionBacteriuriaDiagnostic accuracyYoung adultsDiagnosisAdultsCliniciansFuture studiesStandard definitionSignificant problemSymptomsPrevalence
2012
Surveillance Definitions of Infections in Long-Term Care Facilities: Revisiting the McGeer Criteria
Stone ND, Ashraf MS, Calder J, Crnich CJ, Crossley K, Drinka PJ, Gould CV, Juthani-Mehta M, Lautenbach E, Loeb M, MacCannell T, Malani PN, Mody L, Mylotte JM, Nicolle LE, Roghmann MC, Schweon SJ, Simor AE, Smith PW, Stevenson KB, Bradley SF. Surveillance Definitions of Infections in Long-Term Care Facilities: Revisiting the McGeer Criteria. Infection Control And Hospital Epidemiology 2012, 33: 965-977. PMID: 22961014, PMCID: PMC3538836, DOI: 10.1086/667743.Peer-Reviewed Original ResearchConceptsLong-term care facilitiesSurveillance definitionsCare facilitiesClostridum difficile infectionRespiratory tract infectionsExpert consensus panelMcGeer criteriaTract infectionsUrinary tractDifficile infectionConsensus panelNorovirus gastroenteritisInfectionStructured reviewSignificant changesGastroenteritisTract
2011
Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. PMID: 21091203, PMCID: PMC3089439, DOI: 10.1086/657664.Peer-Reviewed Original ResearchAdverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. DOI: 10.1086/657592.Peer-Reviewed Original Research
2010
Infections in Long‐Term Care Facilities
Juthani‐Mehta M, Quagliarello V. Infections in Long‐Term Care Facilities. 2010, 287-303. DOI: 10.1128/9781555816803.ch15.Peer-Reviewed Original ResearchLong-term care facilitiesUrinary tract infectionCare facilitiesCommon community-acquired infectionsRecurrent urinary tract infectionsInfectious diseasesOlder individualsCommunity-acquired infectionsNursing home residentsFluoroquinolone-resistant pneumococciRate of resistanceProsthetic device infectionsInfectious disease entitiesRisk of infectionAge-associated impairmentOutbreak of gastroenteritisLong-term careLTCF residentsAspiration pneumoniaComorbid diseasesTract infectionsComorbid conditionsCommon infectionsFluoroquinolone useRisk factors
2009
Antimicrobial Susceptibility of Bacteria Isolated from Urine Samples Obtained from Nursing Home Residents
Das R, Perrelli E, Towle V, Van Ness PH, Juthani-Mehta M. Antimicrobial Susceptibility of Bacteria Isolated from Urine Samples Obtained from Nursing Home Residents. Infection Control And Hospital Epidemiology 2009, 30: 1116-1119. PMID: 19785518, PMCID: PMC2866029, DOI: 10.1086/647981.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAnti-Bacterial AgentsDrug Resistance, BacterialEnterobacteriaceaeEnterobacteriaceae InfectionsEscherichia coliEscherichia coli InfectionsFemaleHomes for the AgedHumansMaleMicrobial Sensitivity TestsNitrofurantoinNursing HomesTrimethoprim, Sulfamethoxazole Drug CombinationUrinary Tract InfectionsUrineConceptsUrinary tract infectionNursing home residentsTract infectionsHome residentsUrine samplesEmpiric antimicrobial therapyOral antibioticsAntibiotic therapyIndwelling catheterTrimethoprim-sulfamethoxazoleAntimicrobial therapyResistance patternsAntimicrobial susceptibilityPredominant organismTherapyInfectionResidentsCatheterNitrofurantoinClinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study
Juthani‐Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study. Journal Of The American Geriatrics Society 2009, 57: 963-970. PMID: 19490243, PMCID: PMC2692075, DOI: 10.1111/j.1532-5415.2009.02227.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsClinical featuresHome residentsCohort studyTract infectionsMental statusPresence of dysuriaObservational cohort studyArea nursing homesUrine culturePyuriaClinical definitionBacteriuriaHigh riskLower riskDiagnostic uncertaintyNursing homesCombined outcomeDysuriaInfectionUrineOutcomesEpisodesRiskNovel Biomarkers for the Diagnosis of Urinary Tract Infection–-A systematic Review
Nanda N, Juthani-Mehta M. Novel Biomarkers for the Diagnosis of Urinary Tract Infection–-A systematic Review. Biomarker Insights 2009, 4: bmi.s3155. PMID: 19707519, PMCID: PMC2729697, DOI: 10.4137/bmi.s3155.Peer-Reviewed Original ResearchLower urinary tract infectionsUrinary tract infectionClinical presentationNovel biomarkersTract infectionsElevated serum procalcitonin levelsKidney transplant recipientsSerum procalcitonin levelsPediatric age groupExtremes of ageTime of presentationSpinal cord injuryClinical management decisionsPaucity of dataAsymptomatic bacteriuriaProcalcitonin levelsTransplant recipientsAggressive treatmentSignificant morbidityUrine cultureCord injuryInterleukin-6High prevalenceImmunocompromised individualsDiagnostic criteria
2008
Interobserver Variability in the Assessment of Clinical Criteria for Suspected Urinary Tract Infection in Nursing Home Residents
Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Interobserver Variability in the Assessment of Clinical Criteria for Suspected Urinary Tract Infection in Nursing Home Residents. Infection Control And Hospital Epidemiology 2008, 29: 446-449. PMID: 18419369, PMCID: PMC2671070, DOI: 10.1086/586721.Peer-Reviewed Original Research
2007
Testing Measurement Reliability in Older Populations
Van Ness PH, Towle VR, Juthani-Mehta M. Testing Measurement Reliability in Older Populations. Journal Of Aging And Health 2007, 20: 183-197. PMID: 18089767, PMCID: PMC2754259, DOI: 10.1177/0898264307310448.Peer-Reviewed Original ResearchConceptsOlder nursing home residentsMultifactorial health conditionsUrinary tract infectionNursing home residentsRegression modelingTract infectionsClinical featuresHome residentsOlder subgroupOlder populationHealth conditionsConfidence intervalsRegression analysisValidity assessmentReliability statisticsReliability testingAsymptomatic Bacteriuria and Urinary Tract Infection in Older Adults
Juthani-Mehta M. Asymptomatic Bacteriuria and Urinary Tract Infection in Older Adults. Clinics In Geriatric Medicine 2007, 23: 585-594. PMID: 17631235, DOI: 10.1016/j.cger.2007.03.001.Peer-Reviewed Original ResearchRole of Dipstick Testing in the Evaluation of Urinary Tract Infection in Nursing Home Residents
Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Quagliarello V. Role of Dipstick Testing in the Evaluation of Urinary Tract Infection in Nursing Home Residents. Infection Control And Hospital Epidemiology 2007, 28: 889-891. PMID: 17564998, DOI: 10.1086/518752.Peer-Reviewed Original Research