2017
Serious adverse events of older adults in nursing home and community intervention trials
Datta R, Trentalange M, Van Ness PH, McGloin JM, Guralnik JM, Miller ME, Walkup MP, Nadkarni N, Pahor M, Gill TM, Quagliarello V, Juthani-Mehta M, Group F. Serious adverse events of older adults in nursing home and community intervention trials. Contemporary Clinical Trials Communications 2017, 9: 77-80. PMID: 29696228, PMCID: PMC5898490, DOI: 10.1016/j.conctc.2017.12.004.Peer-Reviewed Original ResearchUnanticipated serious adverse eventsSerious adverse eventsNursing home residentsTotal serious adverse eventsHome residentsSAE incidenceAdverse eventsClinical trialsOlder adultsCommunity dwellersNursing homesIncidence of SAEsFemale nursing home residentsProportion of patientsRandomized clinical trialsCommunity intervention trialStructured physical activityCranberry capsulesLifestyle interventionRandomized trialsIntervention trialsElders StudyHealth centersSecondary data analysisPhysical activity
2015
Antibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo
Madden GR, Argraves SM, Van Ness PH, Juthani-Mehta M. Antibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo. Infection Control And Hospital Epidemiology 2015, 36: 356-357. PMID: 25695180, PMCID: PMC4336946, DOI: 10.1017/ice.2014.66.Peer-Reviewed Original ResearchConceptsNursing home residentsCranberry capsulesUrinary isolatesHome residentsAntibiotic susceptibilityPlacebo
2014
A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders
Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders. Clinical Infectious Diseases 2014, 60: 849-857. PMID: 25520333, PMCID: PMC4415071, DOI: 10.1093/cid/ciu935.Peer-Reviewed Original ResearchConceptsNursing home residentsUsual careHome residentsIntervention protocolFirst pneumoniaControl armClinical trialsNursing homesMultivariable Cox regression modelsElderly nursing home residentsCluster-randomized clinical trialImportant public health problemChlorhexidine oral rinseModifiable risk factorsRespiratory tract infectionsCox regression modelNursing home eldersPublic health problemHazard ratioPneumonia preventionSecondary outcomesTract infectionsControlled TrialsPrimary outcomeOral rinseInnate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders
Juthani-Mehta M, Guo X, Shaw AC, Towle V, Ning Y, Wang X, Allore HG, Fikrig E, Montgomery RR. Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders. Journal Of Aging Science 2014, 02 PMID: 25750929, PMCID: PMC4348001, DOI: 10.4172/2329-8847.1000115.Peer-Reviewed Original ResearchNursing home residentsΒ2-integrin expressionToll-like receptorsHome residentsInnate immune responseImmune responseIntegrin CD11bDisabled nursing home residentsIntegrin expressionΒ2 integrin CD11bLevels of chemokinesObservational pilot studyArea nursing homesNursing home eldersLocomotion of neutrophilsTLR4 responseChemokine inductionInfectious disease susceptibilityCommunity dwellingCommunity dwellersNursing homesEfficiency of neutrophilsNeutrophilsUnstimulated neutrophilsFlow cytometry
2013
Lack of Positive Association Between Falls and Bacteriuria Plus Pyuria in Older Nursing Home Residents
Rowe T, Towle V, Van Ness P, Juthani‐Mehta M. Lack of Positive Association Between Falls and Bacteriuria Plus Pyuria in Older Nursing Home Residents. Journal Of The American Geriatrics Society 2013, 61: 653-654. PMID: 23581923, PMCID: PMC3628627, DOI: 10.1111/jgs.12177.Peer-Reviewed Original Research
2012
Pilot Randomized Controlled Dosing Study of Cranberry Capsules for Reduction of Bacteriuria Plus Pyuria in Female Nursing Home Residents
Bianco L, Perrelli E, Towle V, Van Ness P, Juthani‐Mehta M. Pilot Randomized Controlled Dosing Study of Cranberry Capsules for Reduction of Bacteriuria Plus Pyuria in Female Nursing Home Residents. Journal Of The American Geriatrics Society 2012, 60: 1180-1181. PMID: 22690994, PMCID: PMC3375874, DOI: 10.1111/j.1532-5415.2012.03976.x.Peer-Reviewed Original ResearchConceptsFemale nursing home residentsNursing home residentsCranberry capsulesDosing studyHome residentsPyuriaBacteriuria
2011
Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. PMID: 21091203, PMCID: PMC3089439, DOI: 10.1086/657664.Peer-Reviewed Original ResearchAdverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. DOI: 10.1086/657592.Peer-Reviewed Original Research
2010
Infectious Diseases in the Nursing Home Setting: Challenges and Opportunities for Clinical Investigation
High K, Juthani-Mehta M, Quagliarello V. Infectious Diseases in the Nursing Home Setting: Challenges and Opportunities for Clinical Investigation. Clinical Infectious Diseases 2010, 51: 931-936. PMID: 20822459, PMCID: PMC3083824, DOI: 10.1086/656411.Peer-Reviewed Original ResearchConceptsNursing home residentsHome residentsInfectious diseasesNursing homesNursing home settingMultiple comorbid diseasesPublic health problemComorbid diseasesHigh prevalenceFunctional declineClinical investigationPhysician investigatorsHealth problemsDiseaseHome settingOlder AmericansUnique issuesResidentsImmunosenescencePrognosisDementiaInfectionPrevalenceDiagnosisInfections in Long‐Term Care Facilities
Juthani‐Mehta M, Quagliarello V. Infections in Long‐Term Care Facilities. 2010, 287-303. DOI: 10.1128/9781555816803.ch15.Peer-Reviewed Original ResearchLong-term care facilitiesUrinary tract infectionCare facilitiesCommon community-acquired infectionsRecurrent urinary tract infectionsInfectious diseasesOlder individualsCommunity-acquired infectionsNursing home residentsFluoroquinolone-resistant pneumococciRate of resistanceProsthetic device infectionsInfectious disease entitiesRisk of infectionAge-associated impairmentOutbreak of gastroenteritisLong-term careLTCF residentsAspiration pneumoniaComorbid diseasesTract infectionsComorbid conditionsCommon infectionsFluoroquinolone useRisk factors
2009
Antimicrobial Susceptibility of Bacteria Isolated from Urine Samples Obtained from Nursing Home Residents
Das R, Perrelli E, Towle V, Van Ness PH, Juthani-Mehta M. Antimicrobial Susceptibility of Bacteria Isolated from Urine Samples Obtained from Nursing Home Residents. Infection Control And Hospital Epidemiology 2009, 30: 1116-1119. PMID: 19785518, PMCID: PMC2866029, DOI: 10.1086/647981.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAnti-Bacterial AgentsDrug Resistance, BacterialEnterobacteriaceaeEnterobacteriaceae InfectionsEscherichia coliEscherichia coli InfectionsFemaleHomes for the AgedHumansMaleMicrobial Sensitivity TestsNitrofurantoinNursing HomesTrimethoprim, Sulfamethoxazole Drug CombinationUrinary Tract InfectionsUrineConceptsUrinary tract infectionNursing home residentsTract infectionsHome residentsUrine samplesEmpiric antimicrobial therapyOral antibioticsAntibiotic therapyIndwelling catheterTrimethoprim-sulfamethoxazoleAntimicrobial therapyResistance patternsAntimicrobial susceptibilityPredominant organismTherapyInfectionResidentsCatheterNitrofurantoinPilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents
Quagliarello V, Juthani‐Mehta M, Ginter S, Towle V, Allore H, Tinetti M. Pilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents. Journal Of The American Geriatrics Society 2009, 57: 1226-1231. PMID: 19558483, PMCID: PMC2779042, DOI: 10.1111/j.1532-5415.2009.02311.x.Peer-Reviewed Original ResearchConceptsNursing home residentsChlorhexidine oral rinseOral brushingHome residentsOral hygieneStaff adherenceOral rinseIntervention protocolImproved oral hygienePneumonia risk factorsRisk factor reductionPlaque score reductionPrevent PneumoniaChlorhexidine rinseProspective studyRisk factorsScore reductionNursing homesSwallowing techniquesAdherenceBrushingFactor reductionPneumoniaHygieneMonthsClinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study
Juthani‐Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study. Journal Of The American Geriatrics Society 2009, 57: 963-970. PMID: 19490243, PMCID: PMC2692075, DOI: 10.1111/j.1532-5415.2009.02227.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsClinical featuresHome residentsCohort studyTract infectionsMental statusPresence of dysuriaObservational cohort studyArea nursing homesUrine culturePyuriaClinical definitionBacteriuriaHigh riskLower riskDiagnostic uncertaintyNursing homesCombined outcomeDysuriaInfectionUrineOutcomesEpisodesRisk
2008
Interobserver Variability in the Assessment of Clinical Criteria for Suspected Urinary Tract Infection in Nursing Home Residents
Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Interobserver Variability in the Assessment of Clinical Criteria for Suspected Urinary Tract Infection in Nursing Home Residents. Infection Control And Hospital Epidemiology 2008, 29: 446-449. PMID: 18419369, PMCID: PMC2671070, DOI: 10.1086/586721.Peer-Reviewed Original Research
2007
Testing Measurement Reliability in Older Populations
Van Ness PH, Towle VR, Juthani-Mehta M. Testing Measurement Reliability in Older Populations. Journal Of Aging And Health 2007, 20: 183-197. PMID: 18089767, PMCID: PMC2754259, DOI: 10.1177/0898264307310448.Peer-Reviewed Original ResearchConceptsOlder nursing home residentsMultifactorial health conditionsUrinary tract infectionNursing home residentsRegression modelingTract infectionsClinical featuresHome residentsOlder subgroupOlder populationHealth conditionsConfidence intervalsRegression analysisValidity assessmentReliability statisticsReliability testingAsymptomatic Bacteriuria and Urinary Tract Infection in Older Adults
Juthani-Mehta M. Asymptomatic Bacteriuria and Urinary Tract Infection in Older Adults. Clinics In Geriatric Medicine 2007, 23: 585-594. PMID: 17631235, DOI: 10.1016/j.cger.2007.03.001.Peer-Reviewed Original ResearchRole of Dipstick Testing in the Evaluation of Urinary Tract Infection in Nursing Home Residents
Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Quagliarello V. Role of Dipstick Testing in the Evaluation of Urinary Tract Infection in Nursing Home Residents. Infection Control And Hospital Epidemiology 2007, 28: 889-891. PMID: 17564998, DOI: 10.1086/518752.Peer-Reviewed Original ResearchDiagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*
Juthani‐Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Diagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*. Journal Of The American Geriatrics Society 2007, 55: 1072-1077. PMID: 17608881, DOI: 10.1111/j.1532-5415.2007.01217.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsNegative predictive valuePositive predictive valueConsensus-based criteriaLaboratory evidenceHome residentsTract infectionsPredictive valueEvidence-based clinical criteriaDiagnostic accuracyProspective cohort studySimilar test characteristicsMcGeer criteriaUTI criteriaCohort studyProspective surveillanceUrine cultureClinical criteriaNursing homesTest characteristicsInfectionLoeb criteriaParticipantsSpecificity
2005
Nursing Home Practitioner Survey of Diagnostic Criteria for Urinary Tract Infections
Juthani‐Mehta M, Drickamer MA, Towle V, Zhang Y, Tinetti ME, Quagliarello VJ. Nursing Home Practitioner Survey of Diagnostic Criteria for Urinary Tract Infections. Journal Of The American Geriatrics Society 2005, 53: 1986-1990. PMID: 16274383, DOI: 10.1111/j.1532-5415.2005.00470.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsTract infectionsLaboratory criteriaHome residentsDiagnostic criteriaClinical practiceConsensus criteriaInfection control practitionersFirst diagnostic stepMcGeer criteriaNoncatheterized patientsUrine cultureProspective dataMental statusNineteen physiciansSurveillance criteriaNursing homesPrevention strategiesSelf-administered surveyDipstick analysisDiagnostic stepsPhysician assistantsCharge nursesNurses