Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia
Tong M, Johansson C, Xiao F, Stone PR, James JL, Chen Q, Cree LM, Chamley LW. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Scientific Reports 2017, 7: 16556. PMID: 29185455, PMCID: PMC5707355, DOI: 10.1038/s41598-017-16448-5.Peer-Reviewed Original ResearchMeSH KeywordsAlarminsAntibodies, AntiphospholipidBlotting, WesternCell LineDNA, MitochondrialExtracellular VesiclesFemaleHumansPlacentaPre-EclampsiaPregnancyConceptsRisk of preeclampsiaAntiphospholipid antibodiesTLR-9Placental vesiclesEndothelial cellsFirst trimester human placental explantsMaternal endothelial cell dysfunctionToll-like receptor 9Danger-associated molecular patternsHuman placental explantsPathogenesis of preeclampsiaEndothelial cell dysfunctionEndothelial cell activationPlacental extracellular vesiclesLevels of mtDNAPlacental factorsPlacental explantsReceptor 9Cell dysfunctionNano-vesiclesPreeclampsiaPharmaceutical interventionsCell activationAmount of mtDNAMolecular patternsAggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia
Tong M, Cheng SB, Chen Q, DeSousa J, Stone PR, James JL, Chamley LW, Sharma S. Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific Reports 2017, 7: 6694. PMID: 28751735, PMCID: PMC5532246, DOI: 10.1038/s41598-017-07017-x.Peer-Reviewed Original ResearchConceptsPreeclamptic placentasMaternal circulationNormotensive placentasPreeclampsia-like symptomsProduction of transthyretinPathogenesis of preeclampsiaNano-vesiclesPlacental extracellular vesiclesSerum levelsPreeclamptic seraMaternal organsPreeclampsiaPlacentaTotal transthyretinWestern blottingQRT-PCRExtracellular vesiclesSignificant proportionTransthyretin