2020
Immunology of the Placenta
Tong M, Abrahams VM. Immunology of the Placenta. Obstetrics And Gynecology Clinics Of North America 2020, 47: 49-63. PMID: 32008671, DOI: 10.1016/j.ogc.2019.10.006.ChaptersConceptsMaternal immune regulationMajor immune cellsMaternal-fetal interfaceInnate immune propertiesObstetric complicationsPregnancy complicationsPreterm birthPregnancy lossImmune cellsImmune regulationImmune propertiesHuman placentaPlacentaComplicationsPreeclampsiaPregnancyInfectionKey mechanismImmunology
2018
Immunological effects of placental extracellular vesicles
Tong M, Abrahams VM, Chamley LW. Immunological effects of placental extracellular vesicles. Immunology And Cell Biology 2018, 96: 714-722. PMID: 29604098, DOI: 10.1111/imcb.12049.Peer-Reviewed Original Research
2017
Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia
Tong M, Cheng SB, Chen Q, DeSousa J, Stone PR, James JL, Chamley LW, Sharma S. Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific Reports 2017, 7: 6694. PMID: 28751735, PMCID: PMC5532246, DOI: 10.1038/s41598-017-07017-x.Peer-Reviewed Original ResearchConceptsPreeclamptic placentasMaternal circulationNormotensive placentasPreeclampsia-like symptomsProduction of transthyretinPathogenesis of preeclampsiaNano-vesiclesPlacental extracellular vesiclesSerum levelsPreeclamptic seraMaternal organsPreeclampsiaPlacentaTotal transthyretinWestern blottingQRT-PCRExtracellular vesiclesSignificant proportionTransthyretin
2016
In vivo localisation and vascular effects of nano-vesicles derived from normal first trimester human placentae
Tong M, Stanley J, Chen Q, James J, Stone P, Chamley L. In vivo localisation and vascular effects of nano-vesicles derived from normal first trimester human placentae. Placenta 2016, 45: 67. DOI: 10.1016/j.placenta.2016.06.024.Peer-Reviewed Original ResearchThe reduction in circulating levels of melatonin may be associated with the development of preeclampsia
Zeng K, Gao Y, Wan J, Tong M, Lee A, Zhao M, Chen Q. The reduction in circulating levels of melatonin may be associated with the development of preeclampsia. Journal Of Human Hypertension 2016, 30: 666-671. PMID: 27251079, DOI: 10.1038/jhh.2016.37.Peer-Reviewed Original ResearchConceptsIncidence of preeclampsiaLevels of melatoninDevelopment of preeclampsiaSerum levelsPreeclamptic placentasMelatonin receptorsLate-onset preeclampsiaHealthy pregnant womenPregnancy-specific disorderPathogenesis of preeclampsiaHealthy pregnancyPlacental dysfunctionPregnant womenSuccessful pregnancyPreeclampsiaMelatonin levelsPregnancyIncidenceMelatoninOxidative stressWomenTime onsetPlacentaReceptorsAssociation