2017
Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia
Tong M, Johansson C, Xiao F, Stone PR, James JL, Chen Q, Cree LM, Chamley LW. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Scientific Reports 2017, 7: 16556. PMID: 29185455, PMCID: PMC5707355, DOI: 10.1038/s41598-017-16448-5.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaAntiphospholipid antibodiesTLR-9Placental vesiclesEndothelial cellsFirst trimester human placental explantsMaternal endothelial cell dysfunctionToll-like receptor 9Danger-associated molecular patternsHuman placental explantsPathogenesis of preeclampsiaEndothelial cell dysfunctionEndothelial cell activationPlacental extracellular vesiclesLevels of mtDNAPlacental factorsPlacental explantsReceptor 9Cell dysfunctionNano-vesiclesPreeclampsiaPharmaceutical interventionsCell activationAmount of mtDNAMolecular patterns
2016
Nifedipine prevents endothelial cell activation in response to placental micro- and nano- vesicles released from 1st trimester placental explants that had been treated with preeclamptic sera
Chen Q, Xiao X, Xiao M, Tong M, Wise M, Stone P, Chamley L. Nifedipine prevents endothelial cell activation in response to placental micro- and nano- vesicles released from 1st trimester placental explants that had been treated with preeclamptic sera. Placenta 2016, 45: 120. DOI: 10.1016/j.placenta.2016.06.203.Peer-Reviewed Original ResearchEndothelial cell activation