2018
SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts
Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC. SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. Journal Of The American Society Of Nephrology 2018, 29: 2641-2657. PMID: 30341149, PMCID: PMC6218856, DOI: 10.1681/asn.2018060573.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonAdolescentAdultAgedAlbuminuriaAllograftsAnimalsChildChild, PreschoolEnhancer Elements, GeneticFemaleGene Knockdown TechniquesGlomerular Filtration RateHomozygoteHumansKidneyKidney TransplantationMaleMembrane ProteinsMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMiddle AgedPhosphorylationPodocytesPolymorphism, Single NucleotideProto-Oncogene Proteins c-fynRenal Insufficiency, ChronicRNA, Small InterferingSignal TransductionSrc Homology DomainsYoung AdultConceptsDiffuse foot process effacementKnockdown miceFoot process effacementReduced albuminuriaAllograft fibrosisRenal functionDonor kidneysLower GFRRenal fibrosisTGF-b signalingHuman allograftsNephroseq databaseBiopsy samplesProcess effacementProtective roleAlbuminuriaAdult glomeruliHuman podocytesKnockdown podocytesCKDHuman dataPodocytesAllograftsActin cytoskeleton pathwayFibrosis
2014
Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis
Menon MC, Chuang PY, Li Z, Wei C, Zhang W, Luan Y, Yi Z, Xiong H, Woytovich C, Greene I, Overbey J, Rosales I, Bagiella E, Chen R, Ma M, Li L, Ding W, Djamali A, Saminego M, O’Connell P, Gallon L, Colvin R, Schroppel B, He JC, Murphy B. Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis. Journal Of Clinical Investigation 2014, 125: 208-221. PMID: 25437874, PMCID: PMC4382250, DOI: 10.1172/jci76902.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsBeta CateninDisease SusceptibilityEnhancer Elements, GeneticFibrosisGene ExpressionGenetic Association StudiesGenetic LociHEK293 CellsHumansIntronsKidneyKidney DiseasesKidney TransplantationMaleMiceMicrofilament ProteinsPolymorphism, Single NucleotideQuantitative Trait LociRiskSmad3 ProteinTranscription Factor 7-Like 2 ProteinTranscriptional ActivationTransforming Growth Factor beta1ConceptsChronic allograft nephropathyChronic kidney diseaseAllograft fibrosisTGF-β1Development of CANRisk allelesKidney transplant recipientsRenal allograft recipientsGlomerular filtration rateRenal allograft fibrosisTGF-β1 administrationUnilateral ureteric obstructionRenal tubular cellsTranscription factor 7Canonical TGF-β1Cell-specific knockdownAllograft injuryAllograft nephropathyAllograft recipientsTransplant recipientsProspective cohortRenal functionInterstitial fibrosisUreteric obstructionKidney disease