2021
Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes
Zhang Z, Sun Z, Fu J, Lin Q, Banu K, Chauhan K, Planoutene M, Wei C, Salem F, Yi Z, Liu R, Cravedi P, Cheng H, Hao K, O’Connell P, Ishibe S, Zhang W, Coca SG, Gibson IW, Colvin RB, He J, Heeger PS, Murphy B, Menon MC. Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes. Journal Of Clinical Investigation 2021, 131 PMID: 34499625, PMCID: PMC8592534, DOI: 10.1172/jci146643.Peer-Reviewed Original ResearchConceptsDeath-censored allograft lossAPOL1 risk allelesRisk allelesTransplant outcomesDeath-censored renal allograft survivalRenal allograft survivalChronic allograft rejectionKidney transplant waitlistKidney transplant cohortRisk allele carriersAllograft lossAllograft survivalGraft lossRejection episodesTransplant cohortAllograft rejectionDonor kidneysNative kidneysNK cellsImmunomodulatory roleTransplant waitlistAPOL1 genotypeClinical trialsHealthy controlsHispanic recipients
2020
Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis
Zhang Z, Menon MC, Zhang W, Stahl E, Loza BL, Rosales IA, Yi Z, Banu K, Garzon F, Sun Z, Wei C, Huang W, Lin Q, Israni A, Keating BJ, Colvin RB, Hao K, Murphy B. Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis. Kidney International 2020, 98: 758-768. PMID: 32454123, PMCID: PMC7483801, DOI: 10.1016/j.kint.2020.04.039.Peer-Reviewed Original ResearchConceptsAllograft survivalIntimal fibrosisDeath-censored allograft survivalLong-term allograft failureAcute rejection episodesDonor-recipient differencesRenal allograft survivalHuman leukocyte antigen (HLA) lociNon-HLA SNPsLong-term survivalAllograft failureHLA mismatchesKidney recipientsRejection episodesSubclinical rejectionAllograft fibrosisMultivariable analysisHistologic damageR differencesOrgan SharingCox modelFibrosisHLA regionSurvivalGenome-wide single-nucleotide polymorphism array data