2024
Carbapenem-resistant Enterobacterales in solid organ transplant recipients
Boutzoukas A, Dai W, Cober E, Abbo L, Komarow L, Chen L, Hill C, Satlin M, Grant M, Fries B, Patel G, McCarty T, Arias C, Bonomo R, van Duin D, Investigators F, Kanj S, Jabbour J, Zhang F, Lok J, Salata R, Di Castelnuovo V, Gutierrez J, Cober E, Richter S, Anderson D, Evans B, Hill C, Cross H, Baum K, Arias R, Fowler V, Ordoñez K, Jacob J, Li L, Kreiswirth B, Manca C, Chen L, Desai S, Herc E, Cordova E, Rioseco M, Vichez S, Sanchez M, Valderrama S, Figueroa J, Arias C, Dinh A, Panesso D, Rydell K, Tran T, Hu F, Su J, Jiang J, Wang M, Xu X, Yang Y, Munita J, Spencer M, Alenazi T, Bonomo R, Marshall S, Rudin S, Huskins C, Kerry, Patel R, Schmidt-Malan S, Revolinski S, Wortmann G, Kalayjian R, Weston G, Ostrowsky B, Patel G, Eiras D, Kim A, Garcia-Diaz J, Salcedo S, Farrell J, Liu Z, Henderson A, Paterson D, Xie Q, Kaye K, Gao H, Yu Y, Waters M, Fries B, Eilertson B, Marimuthu K, Chew K, Smitasin N, Tambyah P, Gallagher J, Peleg A, Leroi M, Li L, Komarow L, Ge L, Evans S, McCarty T, Chambers H, Garner O, Abbo L, van Duin D, Lautenbach E, Han J, Doi Y, Wong D, Hanson B, Reyes J, Botero M, Diaz L, Perez F, Banerjee R, Dhar S, Satlin M, Zong Z. Carbapenem-resistant Enterobacterales in solid organ transplant recipients. American Journal Of Transplantation 2024 PMID: 39522694, DOI: 10.1016/j.ajt.2024.10.020.Peer-Reviewed Original ResearchSolid organ transplant recipientsCarbapenem-resistant EnterobacteralesOrgan transplant recipientsTransplant recipientsCohort studyAll-cause 30-day mortalityStabilized inverse probabilityMatched cohort studyCarbapenem resistanceMalignancy historyClinical isolatesAdmitted from homeMatched patientsTransplant historyInfection criteriaAll-causeInverse probabilityMortality riskEnterobacteralesMortalityOutcomesRecipientsMalignancyMulticenterTransplantation
2022
Poor outcomes in both infection and colonization with carbapenem-resistant Enterobacterales
Howard-Anderson JR, Earley M, Komarow L, Abbo L, Anderson DJ, Gallagher JC, Grant M, Kim A, Bonomo RA, van Duin D, Muñoz-Price LS, Jacob JT. Poor outcomes in both infection and colonization with carbapenem-resistant Enterobacterales. Infection Control And Hospital Epidemiology 2022, 43: 1840-1846. PMID: 35105408, PMCID: PMC9343470, DOI: 10.1017/ice.2022.4.Peer-Reviewed Original ResearchConceptsCRE colonizationClinical outcomesCRE infectionsTract colonizationEpidemiology of patientsOutcomes of patientsProspective observational cohortCharacteristics of patientsOverall clinical outcomeShort-term acute care hospitalsUrinary tract colonizationCarbapenem-resistant EnterobacteralesRespiratory tract colonizationAcute care hospitalsDesirable clinical outcomesObservational cohortReadmission ratesSecondary outcomesPrimary outcomePoor outcomeUrinary tractRespiratory tractPatientsBetter outcomesClinical cultures
2020
Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study
van Duin D, Arias C, Komarow L, Chen L, Hanson B, Weston G, Cober E, Garner O, Jacob J, Satlin M, Fries B, Garcia-Diaz J, Doi Y, Dhar S, Kaye K, Earley M, Hujer A, Hujer K, Domitrovic T, Shropshire W, Dinh A, Manca C, Luterbach C, Wang M, Paterson D, Banerjee R, Patel R, Evans S, Hill C, Arias R, Chambers H, Fowler V, Kreiswirth B, Bonomo R, Investigators M. Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study. The Lancet Infectious Diseases 2020, 20: 731-741. PMID: 32151332, PMCID: PMC7473597, DOI: 10.1016/s1473-3099(19)30755-8.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant EnterobacteralesCarbapenemase-producing EnterobacteralesCohort studyProspective cohort studyCRE infectionsIndex culturePrimary outcomeK pneumoniaeCRE groupAdmission ratesClinical dataClinical epidemiologyClinical culturesPatientsUS hospitalsDay 107Similar outcomesDisease controlDesirability of outcomeEnterobacteralesUnique isolatesNational InstituteOutcomesWhole-genome sequencingInfection