2024
Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression
Swanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Rothman D, Abdallah C, Juchem C. Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression. NMR In Biomedicine 2024, 37: e5220. PMID: 39054694, DOI: 10.1002/nbm.5220.Peer-Reviewed Original ResearchPosttraumatic stress disorderMedial prefrontal cortexStress disorderPosttraumatic stress disorder patientsPosttraumatic stress disorder diagnosisChronic psychiatric conditionImpact of psychiatric comorbiditiesComorbid MDDPrefrontal cortexDepressive disorderTraumatic stressorsPsychiatric conditionsMDDPsychiatric comorbiditiesNeurotransmitter abnormalitiesConcentrations of glutamateMetabolite abnormalitiesHealthy controlsDisordersPattern of abnormalitiesParticipantsGlutamateIn vivo protonMetabolic abnormalitiesDepression366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders
Del Motte M, Tamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. 366. The Effect of Early Life Trauma on Prefrontal Synaptic Strength in Major Depressive and Posttraumatic Stress Disorders. Biological Psychiatry 2024, 95: s249. DOI: 10.1016/j.biopsych.2024.02.865.Peer-Reviewed Original Research
2016
Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies
Averill L, Murrough J, Abdallah C. Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies. 2016, 99-121. DOI: 10.1007/978-3-319-42925-0_7.Peer-Reviewed Original ResearchRapid antidepressant effectsNeurobiology of depressionRapid antidepressant actionsNovel drug developmentDrug developmentKetamine's rapid antidepressant effectsRapid antidepressant activityOpen-label trialAntidepressant drug developmentKetamine's rapid antidepressant actionsTrauma-related disordersAntidepressant actionAntidepressant effectsAntidepressant medicationKetamine's mechanismSafety profileKetamine responseAntidepressant activityClinical studiesPotential biomarkersPsychotherapeutic treatmentHuman subjectsMedical SciencesDepressionNeurobiology