Featured Publications
High-affinity olfactory receptor for the death-associated odor cadaverine
Hussain A, Saraiva L, Ferrero D, Ahuja G, Krishna V, Liberles S, Korsching S. High-affinity olfactory receptor for the death-associated odor cadaverine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 19579-19584. PMID: 24218586, PMCID: PMC3845148, DOI: 10.1073/pnas.1318596110.Peer-Reviewed Original ResearchConceptsInnate behaviorsOlfactory receptorsSocial cuesOlfactory sensory neuronsNeural circuitsDetect cadaverineCarrion smellsVertebrate olfactionSensory neuronsAmino acids ornithinePhysiologically relevant sourceReceptorsConcomitant activationMolecular basisConcentration of cadaverineTAAR13cNeuronsSpeciesCuesOlfactionBehaviorSmellCadaverine
2015
Molecular and neuronal homology between the olfactory systems of zebrafish and mouse
Saraiva L, Ahuja G, Ivandic I, Syed A, Marioni J, Korsching S, Logan D. Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Scientific Reports 2015, 5: 11487. PMID: 26108469, PMCID: PMC4480006, DOI: 10.1038/srep11487.Peer-Reviewed Original ResearchConceptsDegree of molecular conservationYears of evolutionary divergenceVomeronasal organOlfactory mucosaOlfactory organChemosensory receptor genesOlfactory systemTranscriptome of miceDual olfactory systemEvolutionary divergenceMolecular conservationNeuronal homologRepertoire sizeRNA abundanceMolecular relationshipsCell-specific markersClasses of neuronsMolecular basisChemosensory receptorsMarker genesOrgans of rodentsAbsolute abundanceZebrafishReceptor geneVertebrates
2011
Crypt Neurons Express a Single V1R-Related ora Gene
Oka Y, Saraiva L, Korsching S. Crypt Neurons Express a Single V1R-Related ora Gene. Chemical Senses 2011, 37: 219-227. PMID: 22038944, DOI: 10.1093/chemse/bjr095.Peer-Reviewed Original ResearchConceptsReceptor geneCrypt neuronsOlfactory receptor familyOlfactory receptor genesOlfactory sensory neuron populationNeuronal populationsSensory neuron populationReceptor familySingle receptor geneNeuron–one receptorOlfactory neuronsNeuronal expressionSense of smellNeuronsReceptorsCell typesOra genesCryptExpression patternsExpressionGenesOraCells
2008
Structural and functional diversification in the teleost S100 family of calcium-binding proteins
Kraemer A, Saraiva L, Korsching S. Structural and functional diversification in the teleost S100 family of calcium-binding proteins. BMC Ecology And Evolution 2008, 8: 48. PMID: 18275604, PMCID: PMC2266712, DOI: 10.1186/1471-2148-8-48.Peer-Reviewed Original ResearchConceptsS100 genesS100 gene familyGene familyJawless fishEF-handPatterns of gene gainCartilaginous fishCalcium-binding proteinLocal gene duplicationS100 familyMammalian family membersCell typesCalcium-mediated signalingEF-hand calcium-binding proteinS100 family membersGenomic arrangementTeleost genomesIntron/exon bordersGene lossGene duplicationGene gainFunctional diversificationS100 subfamilyFamily membersEvolutionary origin