Featured Publications
Combinatorial effects of odorants on mouse behavior
Saraiva L, Kondoh K, Ye X, Yoon K, Hernandez M, Buck L. Combinatorial effects of odorants on mouse behavior. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e3300-e3306. PMID: 27208093, PMCID: PMC4988607, DOI: 10.1073/pnas.1605973113.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptorsOdor aversionBehavioral effectsInstinctive behavioral responsesBinary odor mixturesEffects of odorsOdorant receptorsAversive responsesPredator odorMouse behaviorOdor stimuliOdor mixturesOdor responsesOdor perceptionReceptor antagonismBehavioral responsesOdor detectionSingle receptorSensory inputInstinctive behaviorAversionOdorStereotyped natureReceptor inputMouse nosePositive Darwinian selection and the birth of an olfactory receptor clade in teleosts
Hussain A, Saraiva L, Korsching S. Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 4313-4318. PMID: 19237578, PMCID: PMC2657432, DOI: 10.1073/pnas.0803229106.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptorsTAAR genesIntron gainGene familyClass IIIBony fishesOlfactory receptor neuronsPositive Darwinian selectionLocal positive selectionOlfactory receptor gene familyClass III genesOlfactory receptorsOlfactory receptor familyReceptor gene familyOlfactory epitheliumLigand-binding motifsFish genesTeleost lineageReceptor neuronsJawless vertebratesVertebrate evolutionIII genesPositive selectionDarwinian selectionEvolutionary dynamics
2014
Olfactory Receptor Patterning in a Higher Primate
Horowitz L, Saraiva L, Kuang D, Yoon K, Buck L. Olfactory Receptor Patterning in a Higher Primate. Journal Of Neuroscience 2014, 34: 12241-12252. PMID: 25209267, PMCID: PMC4160765, DOI: 10.1523/jneurosci.1779-14.2014.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptorsHuman trace amine-associated receptorDetect social cuesHuman olfactory perceptionOdorant receptorsMammalian olfactory systemOrganization of sensory inputsSocial cuesOlfactory perceptionOlfactory bulbOlfactory systemSensory inputInstinctive behaviorMouse nosePrimatesDifferent domainsOrganizational strategiesReceptor patternsMacaquesReceptorsCuesChemosensory receptorsMiceOlfactionBrain