Featured Publications
Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq
Saraiva L, Ibarra-Soria X, Khan M, Omura M, Scialdone A, Mombaerts P, Marioni J, Logan D. Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq. Scientific Reports 2015, 5: 18178. PMID: 26670777, PMCID: PMC4680959, DOI: 10.1038/srep18178.Peer-Reviewed Original ResearchConceptsMature olfactory sensory neuronsOlfactory sensory neuronsRNA-seqOR genesGene expressionSingle-cell RNA-seqIntact OR genesOlfactory receptorsCell typesSingle-nucleotide polymorphismsOR-expressing OSNsOR gene expressionIntact olfactory receptorsNeuron-one receptor ruleCrude tissue samplesMonoallelic expressionNeuronal cell typesMouse olfactory mucosaMultiple cell typesChemosensory tissuesGenesCellular heterogeneityOlfactory mucosaSensory neuronsNon-neuronal
2021
Odor coding in the mammalian olfactory epithelium
Kurian S, Naressi R, Manoel D, Barwich A, Malnic B, Saraiva L. Odor coding in the mammalian olfactory epithelium. Cell And Tissue Research 2021, 383: 445-456. PMID: 33409650, PMCID: PMC7873010, DOI: 10.1007/s00441-020-03327-1.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsCombinatorial receptor codeReceptor codeMature olfactory sensory neuronsOdorant receptorsMammalian olfactory epitheliumActivation of odorant receptorsOdorant-receptor interactionsOdor codingOlfactory epitheliumOlfactory mucosaSensory neuronsOdor detectionOdorCodeLevel of complexityAntagonistEpitheliumMucosaReceptors
2016
Deconstructing Olfaction with Transcriptomics: From Whole Tissue to Single-Cells, and from Zebrafish to Humans
Saraiva L, Ibarra-Soria X, Aguilera F, Marioni J, Logan D. Deconstructing Olfaction with Transcriptomics: From Whole Tissue to Single-Cells, and from Zebrafish to Humans. 2016 DOI: 10.5339/qfarc.2016.hbpp2867.Peer-Reviewed Original ResearchOlfactory sensory neuronsFluorescence assisted cell sortingMature olfactory sensory neuronsMolecular barcodesOlfactory receptorsDegree of molecular conservationOlfactory mucosaCell type-specific genesDynamics of gene expressionInter-specific levelType-specific genesOR gene repertoireSingle-cellGene expression networksOlfactory systemEvolution of olfactionMolecular heterogeneityPopulation of olfactory sensory neuronsCilia of olfactory sensory neuronsReceptive matesSpecies nichesMolecular conservationRNA-seqGene familyGene repertoire