2024
Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
Gleason C, Dowling N, Kara F, James T, Salazar H, Simo C, Harman S, Manson J, Hammers D, Naftolin F, Pal L, Miller V, Cedars M, Lobo R, Malek-Ahmadi M, Kantarci K. Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study. PLOS Medicine 2024, 21: e1004435. PMID: 39570992, PMCID: PMC11581397, DOI: 10.1371/journal.pmed.1004435.Peer-Reviewed Original ResearchConceptsOral conjugated equine estrogenLatent growth modelingLong-term cognitive effectsCognitive factor scoresCognitive benefitsCognitive performanceFactor scoresBaseline cognitionFollow-upClinical trialsEarly postmenopauseIn-person research visitsYears of follow-upRandomized to placeboMenopausal hormone therapyGlobal cognitive scoreNeuroimaging effectsCognitive measuresCognitive harmLongitudinal cohort studyCognitive changesCognitive slopesCognitive dataTest batteryCognitive functionRacial Disparities In the Outcomes Of Euploid Single Frozen Thawed Embryo Transfer Cycles – analysis of SART-CORS 2016-2018 data
Brioso X, Kuokkanen S, Akerman M, Pal L. Racial Disparities In the Outcomes Of Euploid Single Frozen Thawed Embryo Transfer Cycles – analysis of SART-CORS 2016-2018 data. Fertility And Sterility 2024 PMID: 39069219, DOI: 10.1016/j.fertnstert.2024.07.031.Peer-Reviewed Original ResearchFrozen-thawed embryo transferFrozen-thawed embryo transfer cyclesSART CORSNon-Hispanic white womenNon-Hispanic blacksLive birthsPregnancy lossAutologous frozen-thawed embryo transferDiagnosis of recurrent pregnancy lossMultivariate analysisThawed embryo transfer cyclesSociety for Assisted Reproductive TechnologyEmbryo transfer cyclesLikelihood of live birthHispanic womenRecurrent pregnancy lossWhite womenOutcome Reporting SystemAnti-Mullerian hormoneBody mass indexAssisted reproductive technologyAssociated with diagnosisClinical pregnancyPreterm birthPregnancy outcomesChronicling menstrual cycle patterns across the reproductive lifespan with real-world data
Cunningham A, Pal L, Wickham A, Prentice C, Goddard F, Klepchukova A, Zhaunova L. Chronicling menstrual cycle patterns across the reproductive lifespan with real-world data. Scientific Reports 2024, 14: 10172. PMID: 38702411, PMCID: PMC11068910, DOI: 10.1038/s41598-024-60373-3.Peer-Reviewed Original ResearchAging and Adiposity—Focus on Biological Females at Midlife and Beyond
Rehman A, Lathief S, Charoenngam N, Pal L. Aging and Adiposity—Focus on Biological Females at Midlife and Beyond. International Journal Of Molecular Sciences 2024, 25: 2972. PMID: 38474226, PMCID: PMC10931752, DOI: 10.3390/ijms25052972.Peer-Reviewed Original ResearchChapter 39 Role in reproductive biology and dysfunction in women
Pal L, Taylor H. Chapter 39 Role in reproductive biology and dysfunction in women. 2024, 873-888. DOI: 10.1016/b978-0-323-91386-7.00036-2.Peer-Reviewed Original ResearchVitamin DMaternal vitamin D statusVitamin D inadequacyVitamin D deficiencyVitamin D statusActive hormonal formReproductive physiologyBeneficial roleVitamin D signalingSpectrum of disordersFemale reproductive functionHuman reproductive physiologyD deficiencyD statusDihydroxyvitamin DFemale reproductive physiologyInsulin resistanceCardiovascular diseaseHormonal formMetabolic milieuD signalingReproductive functionPleotropic effectsPathological processesLimited data
2023
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Kara F, Tosakulwong N, Lesnick T, Fought A, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling M, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.073736.Peer-Reviewed Original ResearchGreater WMH volumeKronos Early Estrogen Prevention StudyHormone therapyPostmenopausal womenWMH volumeHigher SBPBlood pressureHT trialsMenopausal womenGreater white matter hyperintensity volumeWhite matter hyperintensity volumeGood CV healthHigher Blood PressureBlood pressure controlDiastolic blood pressureWhite matter injuryBetter cardiovascular healthAssociation of SBPAntihypertensive usersBaseline SBPPremenopausal womenCV healthHigher systolicCardiovascular healthPrevention StudyHigher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Kara F, Tosakulwong N, Lesnick T, Fought A, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling M, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.081628.Peer-Reviewed Original ResearchGreater WMH volumeKronos Early Estrogen Prevention StudyHormone therapyPostmenopausal womenWMH volumeHigher SBPBlood pressureHT trialsMenopausal womenGreater white matter hyperintensity volumeWhite matter hyperintensity volumeGood CV healthHigher Blood PressureBlood pressure controlDiastolic blood pressureWhite matter injuryBetter cardiovascular healthAssociation of SBPAntihypertensive usersBaseline SBPPremenopausal womenCV healthHigher systolicCardiovascular healthPrevention StudyCardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial
Kantarci K, Tosakulwong N, Lesnick T, Kara F, Kendall-Thomas J, Kapoor E, Fields J, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause The Journal Of The North American Menopause Society 2023, 31: 10-17. PMID: 37989141, PMCID: PMC10756493, DOI: 10.1097/gme.0000000000002278.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyOral conjugated equine estrogenConjugated equine estrogensBetter cardiovascular healthHormone therapyEquine estrogensInsulin resistanceMenopausal womenCardiovascular healthClinical trialsHormone therapy trialsPerson clinic visitsDiastolic blood pressureHomeostasis model assessmentSelf-reported diabetesYears of onsetMultisite clinical trialLevels of glucoseMicronized progesteroneDiabetes medicationsStudy of participantsCardiometabolic effectsCardiometabolic outcomesClinic visitsBlood pressureDisposition of Abandoned Cryopreserved Human Embryos
Torrealday S, Jindal S, Pal L. Disposition of Abandoned Cryopreserved Human Embryos. 2023, 133-139. DOI: 10.1007/978-3-031-41215-8_15.Peer-Reviewed Original ResearchGOOD OBSTETRICAL OUTCOME IS COMPROMISED IN PREGNANCIES RESULTING FROM SINGLE FROZEN-THAWED EUPLOID EMBRYO TRANSFERS (FET) IN WOMEN WITH PCOS
Kuokkanen S, Geraci S, Akerman M, Pal L. GOOD OBSTETRICAL OUTCOME IS COMPROMISED IN PREGNANCIES RESULTING FROM SINGLE FROZEN-THAWED EUPLOID EMBRYO TRANSFERS (FET) IN WOMEN WITH PCOS. Fertility And Sterility 2023, 120: e2. DOI: 10.1016/j.fertnstert.2023.08.066.Peer-Reviewed Original ResearchExamining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016
Beroukhim G, Kayani J, Taylor H, Pal L. Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016. Menopause The Journal Of The North American Menopause Society 2023, 30: 906-912. PMID: 37625087, DOI: 10.1097/gme.0000000000002233.Peer-Reviewed Original ResearchConceptsMenopausal statusBody mass indexSmoking exposureMass indexNational HealthLinear regression analysisTCS levelsTriclosan levelsRetrospective cross-sectional studyMultivariable linear regression analysisReproductive health questionnaireUrinary triclosan levelsDuration of menopauseMultivariate linear regression analysisNutrition Examination SurveyCross-sectional studyYears of ageRegression analysisFemale participantsPostmenopausal statusPostmenopausal womenPremenopausal womenSurgical menopausePremature menopauseUrinary levelsHigher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study
Kara F, Tosakulwong N, Lesnick T, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling N, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.064187.Peer-Reviewed Original ResearchKronos Early Estrogen Prevention StudyDiastolic blood pressureGreater WMH volumeWM injuryWMH volumeWM hyperintensitiesPostmenopausal womenBlood pressureMenopausal transitionRisk factorsHigher white matter hyperintensity volumeWaist/hip ratioWhite matter hyperintensity volumeHormone therapy trialsCVD risk factorsMenopausal hormone therapyWM integrityWhite matter injuryAssociation of BPBetter cardiovascular healthEarly postmenopausal stageLow-density lipoproteinContinuation studyTotal intracranial volumeBaseline SBPTestosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BPVitamin D and infertility
Simpson S, Pal L. Vitamin D and infertility. Current Opinion In Obstetrics & Gynecology 2023, 35: 300-305. PMID: 37266579, DOI: 10.1097/gco.0000000000000887.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeVitamin DGynaecological disordersVitamin D serum levelsOvarian reserve parametersD serum levelsVitamin D deficiencyVitamin D statusDiminished ovarian reserveCommon gynaecological disorderReproductive health burdenHigher pregnancy rateD deficiencyD statusOvarian reserveOvarian syndromeInfertile womenSerum levelsUterine myomaMenstrual regularityEndometriosis patientsInsulin levelsUterine fibroidsHealth burdenPregnancy rateTestosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome
Stone T, Cardozo L, Oluwatade T, Leone C, Okifo F, Reckelhoff J, Pal L, Stachenfeld N. Testosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome. Physiology 2023, 38: 5729543. DOI: 10.1152/physiol.2023.38.s1.5729543.Peer-Reviewed Original ResearchLower body negative pressureBlood pressureHormone interventionSympathetic baroreflexAutonomic functionSimilar systolic blood pressureGonadotropin-releasing hormone antagonistInsulin-resistant womenDiastolic blood pressurePolycystic ovary syndromeSystolic blood pressureCardiovascular autonomic controlBody negative pressureMSNA activitySerum angiotensinOvarian syndromeOvary syndromeResistant womenBaroreflex sensitivityHormone suppressionSerum aldosteroneAutonomic perturbationsT elevationHormone antagonistElevated androgensGenital tuberculosis, infertility and assisted reproduction
Mir N, Pal L. Genital tuberculosis, infertility and assisted reproduction. Current Opinion In Obstetrics & Gynecology 2023, 35: 263-269. PMID: 36912346, DOI: 10.1097/gco.0000000000000866.Peer-Reviewed Original ResearchConceptsGenital tuberculosisClinical presentationLife-threatening risksGenital TBFetal morbidityInfertile womenCouple infertilityAppropriate screeningTimely treatmentRisk populationsUntreated casesInfertilityAssisted reproductionReproductive technologiesUnique risksTuberculosisRiskPresentationMorbidityIVFEpidemiologyDiagnosisRecent literatureWomenImproving preparedness of emergency medicine residents in the management of postpartum hemorrhage: A randomized controlled study of two pedagogical approaches
Casper S, Kayani T, Galerneau F, Evans L, Pal L. Improving preparedness of emergency medicine residents in the management of postpartum hemorrhage: A randomized controlled study of two pedagogical approaches. International Journal Of Gynecology & Obstetrics 2023, 161: 1033-1039. PMID: 36527258, DOI: 10.1002/ijgo.14631.Peer-Reviewed Original ResearchConceptsPostpartum hemorrhagePPH managementEmergency medicine residentsManagement of PPHMedicine residentsPost-intervention assessmentT-testStudent's t-testClinical skills scoresBaseline testingImprovement of knowledgeParticipants' knowledgeDidactic lecturesHemorrhageEM residentsSimulation-based trainingDidactic sessionsForm of interventionEffects of covariatesAddition of simulationStructured curriculumNovel curriculumParticipants
2022
Follicle-stimulating hormone (and luteinizing hormone) in ovarian stimulation: Does the dose matter for cycle success?
Kuokkanen S, Pal L. Follicle-stimulating hormone (and luteinizing hormone) in ovarian stimulation: Does the dose matter for cycle success? Fertility And Sterility 2022, 119: 166-169. PMID: 36529184, DOI: 10.1016/j.fertnstert.2022.12.019.Peer-Reviewed Original ResearchAssociations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy
Kling J, Dowling N, Bimonte-Nelson H, Gleason C, Kantarci K, Stonnington C, Harman S, Naftolin F, Pal L, Cedars M, Manson J, James T, Brinton E, Miller V. Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy. Maturitas 2022, 167: 113-122. PMID: 36395695, PMCID: PMC10077876, DOI: 10.1016/j.maturitas.2022.10.002.Peer-Reviewed Original ResearchConceptsComplex attention tasksLatent growth curve modelsPoor cognitive performancePoorer global cognitionGrowth curve modelsAuditory attentionAttention taskCognitive factorsMental flexibilityVisual attentionExecutive functionCognitive domainsCognitive performanceCognitive trajectoriesGlobal cognitionPituitary-ovarian hormonesHormone therapyBaseline cognitionCognitionHormone levelsNeuropsychological testingMonth 18Menopausal womenEstrone levelsMonth 48RACIAL DISPARITIES IN OUTCOMES OF PREGNANCIES RESULTING FROM PGT-A SINGLE BLASTOCYST TRANSFER - ANALYSIS OF 79, 416 FROZEN-EMBRYO TRANSFER CYLCES IN SART CORS
Pal L, Akerman M, Kuokkanen S. RACIAL DISPARITIES IN OUTCOMES OF PREGNANCIES RESULTING FROM PGT-A SINGLE BLASTOCYST TRANSFER - ANALYSIS OF 79, 416 FROZEN-EMBRYO TRANSFER CYLCES IN SART CORS. Fertility And Sterility 2022, 118: e204. DOI: 10.1016/j.fertnstert.2022.08.579.Peer-Reviewed Original Research