2023
Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BPTestosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome
Stone T, Cardozo L, Oluwatade T, Leone C, Okifo F, Reckelhoff J, Pal L, Stachenfeld N. Testosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome. Physiology 2023, 38: 5729543. DOI: 10.1152/physiol.2023.38.s1.5729543.Peer-Reviewed Original ResearchLower body negative pressureBlood pressureHormone interventionSympathetic baroreflexAutonomic functionSimilar systolic blood pressureGonadotropin-releasing hormone antagonistInsulin-resistant womenDiastolic blood pressurePolycystic ovary syndromeSystolic blood pressureCardiovascular autonomic controlBody negative pressureMSNA activitySerum angiotensinOvarian syndromeOvary syndromeResistant womenBaroreflex sensitivityHormone suppressionSerum aldosteroneAutonomic perturbationsT elevationHormone antagonistElevated androgens
2022
Polycystic ovary syndrome and black race are associated with increased blood pressure
Okifo N, Pal L, Mushi M, Stachenfeld N. Polycystic ovary syndrome and black race are associated with increased blood pressure. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3724.Peer-Reviewed Original ResearchOlder reproductive age womenReproductive-age womenNon-obese groupPolycystic ovary syndromeMultivariable linear regression modelsBlood pressureAge womenObese groupBlack raceBP indicesOvary syndromeRacial breakdownDiagnosis of PCOSNon-obese womenCardiovascular disease riskMultivariable linear regressionType II diabetesLinear regression modelsGreater systolicTubal infertilityIndependent predictorsCommon endocrinopathyRegression modelsBP measurementsPCOSEmerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS
Simpson S, Pal L, Seifer D. Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS. 2022, 489-509. DOI: 10.1007/978-3-030-92589-5_24.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitamin D deficiencyD deficiencyVitamin DDiabetes mellitusCardiovascular diseaseInsulin resistanceContext of PCOSPathogenesis of PCOSType 2 diabetes mellitusParacrine/autocrine roleSpectrum of morbidityMultiple clinical studiesPoor reproductive outcomesAbnormal reproductive functionFeatures of depressionNonhuman primate studiesFemale reproductive tractImpaired folliculogenesisOvary syndromeEndometrial cancerCommon endocrinopathySkeletal healthClinical associationsLifetime riskSurgical Management of Polycystic Ovary Syndrome: A Contemporary Viewpoint on Place of Ovarian Surgery in PCOS Management
Taylor-Giorlando M, Pal L. Surgical Management of Polycystic Ovary Syndrome: A Contemporary Viewpoint on Place of Ovarian Surgery in PCOS Management. 2022, 363-374. DOI: 10.1007/978-3-030-92589-5_18.Peer-Reviewed Original ResearchPolycystic ovary syndromeLaparoscopic ovarian drillingOvarian wedge resectionSurgical managementOvulatory dysfunctionOvary syndromeWedge resectionMedical therapySurgical interventionTherapeutic optionsManagement of PCOSCost-effective therapeutic optionBariatric surgical interventionEarly therapeutic optionConventional medical therapyBariatric surgical proceduresSubgroup of patientsSerious adverse effectsInvasive surgical managementManagement of infertilityTreatment-related risksPopulation of womenComparable success ratesCortical traumaOvarian drilling
2021
Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS
Stone T, Chiles M, Leone C, Pal L, Stachenfeld N. Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.04149.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityLower body negative pressureSympathetic baroreflex sensitivityPolycystic ovary syndromeBaroreflex sensitivityBR controlDiastolic BPHormone suppressionImpaired blood pressure regulationGonadotropin-releasing hormone antagonistOral glucose tolerance testDays of GnRHSympathetic nerve activityInsulin-resistant womenMean arterial pressureVascular resistance changesReproductive-age womenGlucose tolerance testBody negative pressureBlood pressure regulationSuppression of E2Bursts/100 heartbeatsCardiovascular comorbiditiesPCOS phenotypeResistant women
2016
Predictors of Scalp Hair Thinning in Women with Polycystic Ovary Syndrome
Ikhena D, Williams J, Naqvi N, Pal L. Predictors of Scalp Hair Thinning in Women with Polycystic Ovary Syndrome. US Endocrinology 2016, 12: 26. DOI: 10.17925/use.2016.12.01.26.Peer-Reviewed Original ResearchPolycystic ovary syndromeLow-density lipoproteinOvary syndromeHair thinningTwo-hour oral glucose tolerance testSymptoms of PCOSOral glucose tolerance testMultivariable logistic regression analysisTertiary care teaching institutionSerum androgen levelsSerum low-density lipoproteinBody mass indexGlucose tolerance testMain outcome measuresCross-sectional studyLogistic regression analysisQuality of lifeIndependent predictorsMass indexSmoking statusAcanthosis nigricansTolerance testDisturbed sleepMetabolic predictorsAndrogen levels
2014
Polycystic Ovary Syndrome
Pal L, Keefe K. Polycystic Ovary Syndrome. DeckerMed Medicine 2014 DOI: 10.2310/im.1251.ChaptersPolycystic ovary syndromeOvary syndromeManagement of PCOSTreatment of PCOSNational Cholesterol Education Program criteriaFerriman-Gallwey scoring systemType 2 diabetes mellitusCombination of hyperandrogenismObstructive sleep apneaPolycystic ovarian morphologyBody mass indexAdditional sequelaeAnovulatory infertilityPCOS patientsEndometrial hyperplasiaMenstrual disturbancesDiabetes mellitusEndometrial cancerMetabolic syndromeMultifollicular ovariesNonobese womenMass indexSleep apneaEndocrine disordersInsulin resistance
2013
Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS
Lathief S, Pal L. Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS. 2013, 317-331. DOI: 10.1007/978-1-4614-8394-6_19.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitamin D deficiencyD deficiencyInsulin resistanceVitamin DDiabetes mellitusCardiovascular diseasePathogenesis of PCOSPathophysiology of PCOSType 2 diabetes mellitusSpectrum of morbidityPoor reproductive outcomesFeatures of depressionImpaired folliculogenesisOvary syndromeEndometrial cancerCommon endocrinopathyEndocrine featuresSkeletal healthAutoimmune diseasesLifetime riskReproductive agePathophysiologic roleMetabolic milieuMood disorders
2012
Advances in Treatment Options for Polycystic Ovary Syndrome
Lathief S, Pal L. Advances in Treatment Options for Polycystic Ovary Syndrome. US Endocrinology 2012, 08: 57. DOI: 10.17925/use.2012.08.01.57.Peer-Reviewed Original ResearchManagement of PCOSPolycystic ovary syndromePathophysiology of PCOSClomiphene citrateOvary syndromeGonadotropin-releasing hormone antagonistPCOS-related infertilityOvarian stimulation protocolsFirst-line strategyRisk of diabetesAlternative medical therapiesClinical management paradigmsOvarian drillingAnovulatory infertilityOvulatory infertilityAndrogen excessMenstrual irregularitiesOvulation inductionPCOS symptomsMedical therapyCommon endocrinopathyHormonal contraceptivesMenstrual disordersInsulin sensitizersTherapeutic options
2011
Vitamin D deficiency is predictive of depressive symptoms in women with polycystic ovary syndrome (PCOS)
Moore A, Naqvi S, Latif S, Setukavala D, Bevilacqua K, Pal L. Vitamin D deficiency is predictive of depressive symptoms in women with polycystic ovary syndrome (PCOS). Fertility And Sterility 2011, 96: s11-s12. DOI: 10.1016/j.fertnstert.2011.07.051.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitamin D deficiencyD deficiencyOvary syndromeDepressive symptomsSyndromeSymptomsWomen