2024
Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
Gleason C, Dowling N, Kara F, James T, Salazar H, Simo C, Harman S, Manson J, Hammers D, Naftolin F, Pal L, Miller V, Cedars M, Lobo R, Malek-Ahmadi M, Kantarci K. Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study. PLOS Medicine 2024, 21: e1004435. PMID: 39570992, PMCID: PMC11581397, DOI: 10.1371/journal.pmed.1004435.Peer-Reviewed Original ResearchConceptsOral conjugated equine estrogenLatent growth modelingLong-term cognitive effectsCognitive factor scoresCognitive benefitsCognitive performanceFactor scoresBaseline cognitionFollow-upClinical trialsEarly postmenopauseIn-person research visitsYears of follow-upRandomized to placeboMenopausal hormone therapyGlobal cognitive scoreNeuroimaging effectsCognitive measuresCognitive harmLongitudinal cohort studyCognitive changesCognitive slopesCognitive dataTest batteryCognitive function
2023
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study
Kara F, Tosakulwong N, Lesnick T, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling N, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.064187.Peer-Reviewed Original ResearchKronos Early Estrogen Prevention StudyDiastolic blood pressureGreater WMH volumeWM injuryWMH volumeWM hyperintensitiesPostmenopausal womenBlood pressureMenopausal transitionRisk factorsHigher white matter hyperintensity volumeWaist/hip ratioWhite matter hyperintensity volumeHormone therapy trialsCVD risk factorsMenopausal hormone therapyWM integrityWhite matter injuryAssociation of BPBetter cardiovascular healthEarly postmenopausal stageLow-density lipoproteinContinuation studyTotal intracranial volumeBaseline SBP
2021
Waist‐hip ratio as a moderator of the effects of hormone therapy on cognitive function in recently menopausal women
James T, Dowling N, Simó C, Zuelsdorff M, Bouges S, Lambrou N, Van Hulle C, Johnson A, Wyman M, Salazar H, Umucu E, Kara F, Manson J, Brinton E, Cedars M, Lobo R, Neal‐Perry G, Santoro N, Naftolin F, Harman S, Pal L, Miller V, Kantarci K, Gleason C. Waist‐hip ratio as a moderator of the effects of hormone therapy on cognitive function in recently menopausal women. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056539.Peer-Reviewed Original ResearchWomen's Health Initiative Memory StudyCognitive functionInteraction effectsAuditory attentionMental flexibilityVerbal learningVisual attentionCognitive domainsExecutive functionCognitive responsesCognitive testsCognitive benefitsCognitive parametersTime-invariant covariatesMemory studiesCognitive declineIncident cognitive impairmentCognitive impairmentFactor scoresModeratorMemoryReduction/preventionAttentionMenopausal hormone therapyTask