Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial
Brunner A, Blonquist T, DeAngelo D, McMasters M, Fell G, Hermance N, Winer E, Lindsley R, Hobbs G, Amrein P, Hock H, Steensma D, Garcia J, Luskin M, Stone R, Ballen K, Rosenblatt J, Avigan D, Nahas M, Mendez L, McAfee S, Moran J, Bergeron M, Foster J, Bertoli C, Manning A, McGregor K, Fishman K, Kuo F, Baltay M, Macrae M, Burke M, Behnan T, Wey M, Som T, Ramos A, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg D, Chen Y, Graubert T, Fathi A. Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial. The Lancet Haematology 2019, 7: e122-e133. PMID: 31837959, DOI: 10.1016/s2352-3026(19)30203-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAzepinesCytarabineFemaleFollow-Up StudiesHumansIdarubicinInduction ChemotherapyLeukemia, Myeloid, AcuteMaleMiddle AgedPyrimidinesRisk FactorsConceptsAcute myeloid leukemiaHigh-risk acute myeloid leukemiaTherapy-related acute myeloid leukemiaSecondary acute myeloid leukemiaPhase 2 trialPlatelet count recoveryInduction chemotherapyComplete remissionMyeloid leukemiaUntreated patientsEligible patientsCount recoveryDana-Farber/Harvard Cancer CenterEastern Cooperative Oncology Group performance statusUntreated acute myeloid leukemiaActivity of alisertibAdverse-risk karyotypeCommon grade 3Previous myelodysplastic syndromeTreatment-related deathsProportion of patientsPromising therapeutic targetComposite remissionFebrile neutropeniaOral alisertib