MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia.
Pyzer A, Stroopinsky D, Rajabi H, Washington A, Tagde A, Coll M, Fung J, Bryant M, Cole L, Palmer K, Somaiya P, Karp Leaf R, Nahas M, Apel A, Jain S, McMasters M, Mendez L, Levine J, Joyce R, Arnason J, Pandolfi P, Kufe D, Rosenblatt J, Avigan D. MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia. Blood 2017, 129: 1791-1801. PMID: 28126925, PMCID: PMC5813734, DOI: 10.1182/blood-2016-07-730614.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaSuppressor cellsAML cellsMyeloid leukemiaExtracellular vesiclesDonor peripheral blood mononuclear cellsAutologous T cell responsesCompetent antigen-presenting cellsMyeloid-derived suppressor cellsPeripheral blood mononuclear cellsReduced T-cell proliferationPresence of MDSCsExpansion of MDSCsT cell responsesBlood mononuclear cellsAntigen-presenting cellsPrimary AML cellsT cell proliferationExpansion of CD11bTumor-derived extracellular vesiclesMyeloid progenitor cellsMDSC populationsMDSC expansionImmune toleranceC57BL/6 mice