2003
Altered NMDA Glutamate Receptor Antagonist Response in Recovering Ethanol-Dependent Patients
Krystal JH, Petrakis IL, Limoncelli D, Webb E, Gueorgueva R, D'Souza DC, Boutros NN, Trevisan L, Charney DS. Altered NMDA Glutamate Receptor Antagonist Response in Recovering Ethanol-Dependent Patients. Neuropsychopharmacology 2003, 28: 2020-2028. PMID: 12888778, DOI: 10.1038/sj.npp.1300252.Peer-Reviewed Original ResearchConceptsEthanol-dependent patientsNMDA receptor antagonistReceptor antagonistEthanol dependenceN-methyl-D-aspartate (NMDA) glutamate receptorsDouble-blind studySelective NMDA receptor antagonistNMDA receptor functionAlcohol-dependent patientsHealthy comparison subjectsTreatment of alcoholismHealthy comparison groupExecutive cognitive functionKetamine infusionKetamine 0.5NMDA receptorsGlutamate receptorsComparison subjectsPatientsAmnestic effectsRandomized orderReceptor functionCognitive functionAntagonist responseAntagonist
1994
Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus
Trevisan L, Fitzgerald L, Brose N, Gasic G, Heinemann S, Duman R, Nestler E. Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus. Journal Of Neurochemistry 1994, 62: 1635-1638. PMID: 8133290, DOI: 10.1046/j.1471-4159.1994.62041635.x.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureSubunit immunoreactivityEthanol exposureGlutamate receptorsIsoxazole propionic acid (AMPA) glutamate receptorsPropionic acid glutamate receptorsImportant neurochemical substrateReceptor subunit immunoreactivityGlutamate receptor subunit 1Different neurotransmitter systemsAspartate glutamate receptorsDifferent pharmacological profilesReceptor subunit 1Effects of ethanolChronic administrationChronic treatmentNMDAR1 immunoreactivityCerebral cortexChronic ingestionEthanol dependenceGluR2 proteinRat hippocampusNeurotransmitter systemsNMDAR1 subunitNucleus accumbens