2016
Randomized Trial of Endoscopist-Controlled vs. Assistant-Controlled Wire-Guided Cannulation of the Bile Duct
Buxbaum J, Leonor P, Tung J, Lane C, Sahakian A, Laine L. Randomized Trial of Endoscopist-Controlled vs. Assistant-Controlled Wire-Guided Cannulation of the Bile Duct. The American Journal Of Gastroenterology 2016, 111: 1841. PMID: 27377519, DOI: 10.1038/ajg.2016.268.Peer-Reviewed Original ResearchMeSH KeywordsAdultBile DuctsCatheterizationCholangiopancreatography, Endoscopic RetrogradeCholangitisEarly Termination of Clinical TrialsFemaleGastroenterologistsHemorrhageHumansIntraoperative ComplicationsLogistic ModelsMaleMiddle AgedMultivariate AnalysisNursesPancreatitisPatient SafetyPostoperative ComplicationsPostoperative HemorrhageConceptsBile duct cannulationEndoscopic retrograde cholangiopancreatographySafety end pointDuct cannulationBiliary cannulationInterim analysisWire guidanceComposite safety end pointComplications of ERCPEnd pointPrimary efficacy outcomePost-ERCP pancreatitisSuccessful biliary cannulationSignificant differencesEfficacy outcomesRandomized trialsBile ductRetrograde cholangiopancreatographyCannulation attemptsCannulationPatientsSphincterotomePancreatitisSignificant increaseLower rates
2015
Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP?
Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR. Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP? Digestive Diseases And Sciences 2015, 61: 722-730. PMID: 26572779, DOI: 10.1007/s10620-015-3939-7.Peer-Reviewed Original ResearchConceptsTotal procedure timeProcedure timePrimary outcomeAcademic tertiary referral centerShorter total procedure timeTertiary referral centerPerformance of ERCPReferral centerCohort studyRetrograde cholangiographyERCP proceduresTrainee experienceGastroenterology fellowsSurgical skills centerFlexible endoscopyERCP trainingLittle dataGastroenterology facultyERCPSignificant differencesConsiderable riskSession 2Session 1Baseline sessionsOutcomes
2003
Helicobacter pylori eradication does not benefit non-ulcer dyspepsia
Laine L. Helicobacter pylori eradication does not benefit non-ulcer dyspepsia. 2003, 275-281. DOI: 10.1007/978-94-017-1763-2_28.ChaptersNon-ulcer dyspepsiaH. pylori eradication therapyPylori eradication therapyEradication therapyPylori eradicationH. pylori eradication treatmentH. pylori eradicationHelicobacter pylori eradicationPylori eradication treatmentH. pylori treatmentPylori treatmentEradication treatmentTreatment successDyspepsiaHelicobacter pyloriAetiological agentSerious methodological flawsTrialsSmall benefitPotential roleSignificant differencesMethodological flawsTherapyEradicationTreatment
1996
Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices
Laine L, Stein C, Sharma V. Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices. Gastroenterology 1996, 110: 529-533. PMID: 8566601, DOI: 10.1053/gast.1996.v110.pm8566601.Peer-Reviewed Original ResearchConceptsEsophageal varicesVariceal eradicationCombined therapyTreatment sessionsMajor bleedingMean followEndoscopic sclerotherapyHospital daysRepeat endoscopyRandomized comparisonSclerotherapyVaricesPatientsAbstractTextTherapyMore sessionsLigationEradicationComplicationsSignificant differencesAIMSTreatmentSessionsGreater timeBleeding