2014
Causes of Bleeding and Outcomes in Patients Hospitalized With Upper Gastrointestinal Bleeding
Kim JJ, Sheibani S, Park S, Buxbaum J, Laine L. Causes of Bleeding and Outcomes in Patients Hospitalized With Upper Gastrointestinal Bleeding. Journal Of Clinical Gastroenterology 2014, 48: 113-118. PMID: 23685847, DOI: 10.1097/mcg.0b013e318297fb40.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overEndoscopy, GastrointestinalEsophageal and Gastric VaricesEsophagitisFemaleGastrointestinal HemorrhageHematemesisHospital MortalityHospitalizationHumansLength of StayMaleMedicaidMedicareMelenaMiddle AgedPeptic UlcerPeptic Ulcer HemorrhageRetreatmentRetrospective StudiesUnited StatesConceptsUpper gastrointestinal bleedingGastrointestinal bleedingCommon causeOutcomes of UGIBVariceal upper gastrointestinal bleedingNonvariceal upper gastrointestinal bleedingCause of bleedingRisk of deathLower socioeconomic patientsUrban US hospitalsErosive esophagitisInpatient mortalityRepeat endoscopyUpper endoscopyConsecutive patientsClinical outcomesPeptic ulcerMean ageMedical CenterUrban hospitalPatientsUS hospitalsMultivariate analysisHematemesisEndoscopy
2009
Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference
Laine L, Spiegel B, Rostom A, Moayyedi P, Kuipers EJ, Bardou M, Sung J, Barkun AN. Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference. The American Journal Of Gastroenterology 2009, 105: ajg2009702. PMID: 20029415, DOI: 10.1038/ajg.2009.702.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNonvariceal upper gastrointestinal bleedingUpper gastrointestinal bleedingPrimary end pointInternational Consensus ConferenceGastrointestinal bleedingRandomized trialsConsensus conferenceEnd pointPrimary assessmentManagement of patientsType of lesionPlacebo/Protocol populationRepeat endoscopyLarge trialsRandomization scheduleInclusion criteriaPatientsSmall studyCurrent standard practiceSubsequent interventionsBleedingLiterature searchSample size calculationConservative approach
2004
Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: A double-blind trial
Laine L, Maller ES, Yu C, Quan H, Simon T. Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: A double-blind trial. Gastroenterology 2004, 127: 395-402. PMID: 15300570, DOI: 10.1053/j.gastro.2004.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Inflammatory Agents, Non-SteroidalAspirinCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDouble-Blind MethodDrug Therapy, CombinationFemaleGastric MucosaHumansIbuprofenIncidenceIsoenzymesLactonesMaleMembrane ProteinsMiddle AgedOsteoarthritisProstaglandin-Endoperoxide SynthasesRisk FactorsStomach UlcerSulfonesTablets, Enteric-CoatedConceptsNonselective nonsteroidal anti-inflammatory drugsLow-dose aspirinCOX-2 selective inhibitorsDouble-blind trialUlcer incidenceNonselective NSAIDsLow-dose enteric-coated aspirinLow-dose aspirin usersCyclooxygenase-2 selective inhibitorSelective inhibitorNonsteroidal anti-inflammatory drugsEnteric-coated aspirinGastrointestinal mucosal injuryNumber of erosionsRisk of ulcerAnti-inflammatory drugsCOX-2 selective inhibitionYears of ageBaseline endoscopyAspirin usersDose aspirinErosive esophagitisCumulative incidenceMucosal injuryRepeat endoscopy
1996
Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices
Laine L, Stein C, Sharma V. Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices. Gastroenterology 1996, 110: 529-533. PMID: 8566601, DOI: 10.1053/gast.1996.v110.pm8566601.Peer-Reviewed Original ResearchConceptsEsophageal varicesVariceal eradicationCombined therapyTreatment sessionsMajor bleedingMean followEndoscopic sclerotherapyHospital daysRepeat endoscopyRandomized comparisonSclerotherapyVaricesPatientsAbstractTextTherapyMore sessionsLigationEradicationComplicationsSignificant differencesAIMSTreatmentSessionsGreater timeBleeding