2008
Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials
Laine L, McQuaid KR. Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials. Clinical Gastroenterology And Hepatology 2008, 7: 33-47. PMID: 18986845, DOI: 10.1016/j.cgh.2008.08.016.Peer-Reviewed Original ResearchConceptsEndoscopic therapyProton pump inhibitorsActive bleedingVisible vesselPump inhibitorsIntravenous proton pump inhibitorsAppropriate endoscopic treatmentNonbleeding visible vesselPrimary end pointSecond-look endoscopyEndoscopic hemostatic therapyRandomized Controlled TrialsEvidence-based approachPlacebo/Further bleedingHemostatic therapyInjection therapyControlled TrialsEndoscopic treatmentRandomized trialsBleeding ulcersSclerosant therapyReceptor antagonistBibliographic database searchBleedingSystematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers
Elmunzer BJ, Young SD, Inadomi JM, Schoenfeld P, Laine L. Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers. The American Journal Of Gastroenterology 2008, 103: ajg2008521. PMID: 18684171, DOI: 10.1111/j.1572-0241.2008.02070.x.Peer-Reviewed Original ResearchConceptsEndoscopic therapyIndependent predictorsRecurrent hemorrhageProspective studySystematic reviewIntensive care unit observationLarge ulcer sizePosterior duodenal ulcerSecond-look endoscopyEndoscopic hemostatic therapySignificant independent predictorsPrespecified inclusion criteriaComorbid illnessesHemodynamic instabilityHemostatic therapyDuodenal ulcerEndoscopic predictorsPrimary outcomeUlcer sizeMultivariable analysisPooled ratePeptic ulcerClinical managementBibliographic database searchInclusion criteria
1996
A prospective outcome study of patients with clot in an ulcer and the effect of irrigation
Laine L, Stein C, Sharma V. A prospective outcome study of patients with clot in an ulcer and the effect of irrigation. Gastrointestinal Endoscopy 1996, 43: 107-110. PMID: 8635701, DOI: 10.1016/s0016-5107(06)80109-4.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingEndoscopic therapyVisible vesselActive bleedingFurther bleedingGastrointestinal bleedingHemostatic therapyAdherent clotHigh-risk stigmataLow-risk findingsProspective outcome studyObservation of patientsInitial endoscopyEndoscopic findingsProspective studyExcellent outcomesUlcer baseBleedingClean baseOutcome studiesVigorous irrigationPatientsAppropriate managementVariable prevalenceTherapy
1992
Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis
Cook D, Guyatt G, Salena B, Laine L. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis. Gastroenterology 1992, 102: 139-148. PMID: 1530782, DOI: 10.1016/0016-5085(92)91793-4.Peer-Reviewed Original ResearchConceptsAcute nonvariceal upper gastrointestinal hemorrhageNonvariceal upper gastrointestinal hemorrhageUpper gastrointestinal hemorrhageEndoscopic hemostatic therapyEndoscopic therapyGastrointestinal hemorrhageHemostatic therapyEndoscopic treatmentFlat pigmented spotUpper gastrointestinal bleedingDuplicate independent reviewForm of therapyEnglish-language literatureActive bleedingFurther bleedingGastrointestinal bleedingEndoscopic featuresInjection therapyAdherent clotRelevant trialsSurgery ratesVisible vesselLaser therapyBleedingTherapy