2020
Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia
Gautam S, Stahl Y, Young GM, Howell R, Cohen AJ, Tsang DA, Martin T, Sharma L, Dela Cruz CS. Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2020, 319: l661-l669. PMID: 32783617, PMCID: PMC7642899, DOI: 10.1152/ajplung.00316.2020.Peer-Reviewed Original ResearchConceptsNeutrophil extracellular trapsAcute respiratory distress syndromeChronic obstructive pulmonary diseaseNeutrophil responseExtracellular trapsDysregulation of neutrophilsObstructive pulmonary diseaseRespiratory distress syndromeNeutrophil effector functionsEx vivo assaysBronchoalveolar neutrophilsSevere asthmaDistress syndromeLung neutrophilsPulmonary diseaseMurine pneumoniaMurine modelEffector functionsNeutrophil researchMouse lungCystic fibrosisMethodologic issuesMurine researchLungArray of diseases
2017
The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients
Kim HJ, Kim YS, Kim KH, Choi JP, Kim YK, Yun S, Sharma L, Dela Cruz CS, Lee JS, Oh YM, Lee SD, Lee SW. The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients. Experimental & Molecular Medicine 2017, 49: e316-e316. PMID: 28408748, PMCID: PMC5420800, DOI: 10.1038/emm.2017.7.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCOPD groupLung tissueClinical characteristicsHealthy smokersNormal spirometryPresence of COPDExtracellular vesiclesHealthy smoker groupParticipants' clinical characteristicsSurgical lung tissueObstructive pulmonary diseaseChronic inflammatory diseaseSame mean ageRibosomal RNA gene sequencingRNA gene sequencingCOPD patientsSmoker groupImmune dysfunctionPulmonary diseaseSmoking statusMean ageNanometer-sized extracellular vesiclesLung microbiomeInflammatory diseases