Lloyd G. Cantley, MD
C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular PhysiologyCards
About
Research
Overview
The primary focus of our laboratory is to determine the mechanisms of renal tubule development, homeostasis and repair. When the kidney is injured following ischemia or toxin exposure, the remaining epithelial cells de-differentiate, spread over the denuded basement membrane, divide, and re-arrange themselves in a specific pattern to regenerate functional tubules. This process requires a complex array of events involving rearrangement of cell shape and regulation of cell-matrix and cell-cell interactions. By examining epithelial cell adhesion, migration, and branching tubulogenesis in response to growth factors such as Hepatocyte Growth Factor and chitin's 3-like 1, we are determining the intracellular signaling events critical for tubule formation during kidney development and following injury. We have focused these efforts on the role of activation of specific MAPK isoforms as well as the PI 3-kinase in the regulation of cell morphogenesis and cell-matrix interactions.
In addition, we are examining the role of the innate immune response to kidney injury and found that macrophages home to the injured kidney and initially promote apoptosis of sublethally injured tubular cells. Subsequent macrophage accumulation includes increasing numbers of alternatively activated macrophages that promote the survival and proliferation of the remaining tubular cells to effect tubule repair. We are currently expanding this work to study human acute kidney injury and have developed the use of Imaging Mass Cytometry in the human kidney.
Medical Research Interests
Clinical Care
Overview
Lloyd G. Cantley, MD, is a nephrologist whose clinical practice focuses on kidney disorders such as acute kidney injury, kidney dysfunction, chronic kidney disease and electrolyte imbalances. He is the C. N. H. Long Professor of Medicine in nephrology, professor of cellular and molecular physiology, and co-director of education at the Yale Center for Clinical Investigation.
Dr. Cantley's research explores acute kidney injury, polycystic kidney disease, chronic kidney disease, and the immune system's involvement in kidney disease. His interests include the causes of acute injury and how repair can be optimized, progression of kidney diseases, and the link between kidney diseases and general health.
Dr. Cantley has received awards and support from organizations such as the National Center for Advancing Translational Sciences, the American Heart Association, the National Institute of Diabetes and Digestive and Kidney Diseases, and the Department of Defense.
Clinical Specialties
Board Certifications
Nephrology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1988
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1984
News
News
- December 02, 2024
2025 YCCI Funding Opportunities Open for Applications
- March 20, 2024
The power of collaboration
- November 16, 2023
YCCI Funding Opportunities Open for Applications
- October 24, 2023
Yale Contributions Shape ASN Kidney Week 2023