Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease Subtype
Koutroumpakis F, Phillips AE, Yadav D, Machicado JD, Ahsan M, Rivers C, Tan X, Schwartz M, Proksell S, Johnston E, Dueker J, Hashash JG, Barrie A, Harrison J, Dunn MA, Konnikova L, Hartman DJ, Din H, Babichenko D, Tang G, Binion DG. Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease Subtype. Inflammatory Bowel Diseases 2020, 27: 855-863. PMID: 32879976, DOI: 10.1093/ibd/izaa230.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIgG4 subclass deficiencyIgG4 levelsSubclass deficiencyAntibody deficiencyIgG4 deficiencyDisease severitySevere inflammatory bowel diseaseHigh serum IgG4 levelsInflammatory bowel disease subtypeCD-related surgeryIg replacement therapyLow IgG4 levelsMultiple Poisson regression analysisMore hospital admissionsPrimary sclerosing cholangitisSerum IgG4 levelsCohort of patientsIgG4 serum levelsOutpatient antibiotic prescriptionsAnti-inflammatory moleculesHumoral immune responseInflammatory disease processesPoisson regression analysisElectronic health records