Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin
Mirizio E, Liu C, Yan Q, Waltermire J, Mandel R, Schollaert KL, Konnikova L, Wang X, Chen W, Torok KS. Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin. Frontiers In Pediatrics 2021, 9: 669116. PMID: 34164359, PMCID: PMC8215272, DOI: 10.3389/fped.2021.669116.Peer-Reviewed Original ResearchLocalized sclerodermaLS patientsGene signatureClinical activity parametersPediatric localized sclerodermaSignificant functional disabilityInterferon-inducible chemokinesSkin transcriptional profileIFNγ signatureProgressive diseaseFunctional disabilityInflammatory lesionsLesion biopsyParaffinized tissuesDisease progressionHealthy controlsInflammatory diseasesFibrotic pathwaysScleroderma skinCellular expressionDiseaseL subjectsGene expression profilesSkinIFNγ