2018
382 - High Dimensional Immune Phenotyping Using Mass Cytometry Reveals Unique IL1B Signatures in Peripheral Blood and GI Tissue of Ulcerative Colitis, Crohn's Disease, and IL10R Deficient Patients
Mitsialis V, Shouval D, Wall S, Snapper S, Konnikova L. 382 - High Dimensional Immune Phenotyping Using Mass Cytometry Reveals Unique IL1B Signatures in Peripheral Blood and GI Tissue of Ulcerative Colitis, Crohn's Disease, and IL10R Deficient Patients. Gastroenterology 2018, 154: s-90-s-91. DOI: 10.1016/s0016-5085(18)30750-9.Peer-Reviewed Original Research
2017
Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD
Shouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB. Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflammatory Bowel Diseases 2017, 23: 1950-1961. PMID: 29023267, DOI: 10.1097/mib.0000000000001270.Peer-Reviewed Original ResearchConceptsT cell proliferationDeficient patientsTh17 cellsReceptor deficiencySevere infantile-onset inflammatory bowel diseaseInfantile-onset inflammatory bowel diseaseAdaptive immune cell functionsCD4 T cell functionCD4 T cell proliferationCD4 T cell subsetsHematopoietic stem cell transplantationPeripheral blood mononuclear cellsNaive T cell proliferationSuppression of TregsGeneration of TregsInflammatory bowel diseaseRegulatory T cellsStem cell transplantationT cell subsetsBlood mononuclear cellsImmune cell defectsAnti-inflammatory macrophagesT cell functionImmune cell functionReal-time polymerase chain reaction